老年鼻咽癌患者血浆Ras相关区域家族1A基因、血清转化生长因子-β1及乳铁蛋白的表达及相关性

发布时间：2018-06-16 14:21

  本文选题：鼻咽癌 + Ras相关区域家族(RASSF)A　； 参考：《中国老年学杂志》2017年13期

【摘要】：目的探讨血浆Ras相关区域家族(RASSF)1A基因、转化生长因子(TGF)-β1及乳铁蛋白(LTF)在老年鼻咽癌(NPC)患者及其不同临床病理特征中的表达及相关性。方法 NPC患者50例为NPC组,鼻咽炎患者50例为鼻咽炎组,健康志愿者50例为正常对照组。3组采用定量甲基化特异性聚合酶链反应(PCR)(RQ-MSP)检测RASSF1A基因、血清TGF-β1及LTF的表达情况,并分析相关性。结果 NPC组血浆中RASSF1A、TGF-β1及LTF的表达与鼻咽炎组、正常对照组差异有统计学意义(P0.05)。NPC组血浆RASSF1A、TGF-β1及LTF水平:Ⅰ期与其他期差异显著(P0.01);Ⅲ期与Ⅳa期、Ⅳb期差异有统计学意义(P0.01);未分化癌与鳞癌、腺癌差异显著(P0.01);无淋巴结转移与有淋巴结转移差异有统计学意义(P0.01),颈部和远处淋巴结转移差异有统计学意义(P0.05)。结论 RASSF1A、TGF-β1及LTF在老年鼻咽癌患者血清中表达呈上调或下降趋势,与鼻咽癌分期、病理类型及淋巴结转移相关。
[Abstract]:Objective to investigate the expression and correlation of RASSFF1A gene, TGF- 尾 1 and lactoferrin in elderly patients with nasopharyngeal carcinoma (NPC) and its clinicopathological features. Methods RASSF1A gene, serum TGF- 尾 1 and LTF were detected by quantitative methylation specific polymerase chain reaction (PCR) in 50 NPC patients, 50 nasopharyngitis patients and 50 healthy volunteers as control group. The correlation was analyzed. Results the expression of TGF- 尾 1 and LTF in plasma of NPC group was significantly higher than that of nasopharyngitis group and normal control group. The levels of TGF- 尾 1 and LTF in plasma of NPC group were significantly different from those of other stages, stage 鈪，

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