慢性中耳炎细菌培养与细菌生物膜形成无显著相关

发布时间：2018-06-20 00:38

本文选题：慢性中耳炎 + 细菌培养　；参考：《基因组学与应用生物学》2017年11期

【摘要】：探讨慢性中耳炎细菌培养及细菌生物膜形成的关系分析。选取2015年2月~2017年2月在我院治疗的慢性中耳炎患者143例,其中慢性化脓性中耳炎(活动期)79例,中耳胆脂瘤64例,对患者中耳分泌物进行细菌培养鉴定,同时进行扫描电子显微镜检查。慢性化脓性中耳炎和中耳胆脂瘤患者细菌生物膜阳性率分别为82.28%和71.88%,差异比较无统计学意义(p0.05);143例标本中共有108例检出病原菌,检出率为75.52%;慢性化脓性中耳炎和中耳胆脂瘤细菌培养阳性率分别为72.15%和79.69%,差异比较无统计学意义(p0.05);慢性化脓性中耳炎和中耳胆脂瘤细菌类型分布比较无统计学意义(p0.05);细菌培养结果与细菌生物膜结果无相关性(p0.05);以细菌培养结果预测细菌生物膜的灵敏度、特异度、阳性预测值和阴性预测值分别为76.58%、28.13%、78.70%和25.71%;不同细菌生物膜阳性率比较差异无统计学意义(p0.05)。慢性中耳炎细菌生物膜形成率较高,与细菌培养结果无相关性。
[Abstract]:To explore the relationship between bacterial culture and biofilm formation in chronic otitis media. 143 cases of chronic otitis media treated in our hospital from February 2015 to February 2017 were selected, including 79 cases of chronic suppurative otitis media (79 cases of active otitis media, 64 cases of cholesteatoma of middle ear). Scanning electron microscopy was also performed. The positive rates of bacterial biofilm in patients with chronic suppurative otitis media and cholesteatoma were 82.28% and 71.88 respectively. The positive rates of bacterial culture in chronic suppurative otitis media and middle ear cholesteatoma were 72.15% and 79.69 respectively, the difference was not significant (p 0.05), and the distribution of bacteria in chronic suppurative otitis media and middle ear cholesteatoma was not statistically significant. The results of bacterial culture were not related to the results of bacterial biofilm, and the sensitivity of bacterial biofilm was predicted by the results of bacterial culture. The specificity, positive predictive value and negative predictive value were 76.58% and 25.71%, respectively. There was no significant difference in the positive rate of different bacterial biofilms (P 0.05). The biofilm formation rate of bacteria in chronic otitis media was higher, and there was no correlation between biofilm formation and bacterial culture results.
【作者单位】：昆明医科大学第一附属医院耳鼻喉科;
【基金】：云南省卫生科技计划项目(No.2014NS193)资助
【分类号】：R764.21

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