阻塞性睡眠呼吸暂停综合征与2型糖尿病并发胆石症风险的相关性研究

发布时间：2018-06-20 03:39

本文选题：睡眠呼吸暂停 + 阻塞性　；参考：《中国医药科学》2016年10期

【摘要】：目的探讨阻塞性睡眠呼吸暂停综合征(OSAS)与2型糖尿病(T2DM)患者并发胆石症的相关性。方法对2015年1~12月到我科就诊T2DM住院患者使用便携式睡眠呼吸监测仪进行OSAS筛查,并根据上腹部B超或CT结果进行胆石症患病与否分组,观察两组患者性别、年龄、病程、合并OSAS、糖化血红蛋白(Hb A1c)、高血脂、胰岛素抵抗指数(HOMA-IR)、合并阻塞性睡眠呼吸暂停综合征(OSAS)患者每小时睡眠发生呼吸暂停次数(AI)、每小时睡眠发生呼吸暂停和低通气次数(AHI)、最低脉搏容积血氧饱和度(LSp O2)、呼吸紊乱指数(RDI)的差异,分析OSAS对T2DM并发胆石症的影响。结果完成试验230例,OSAS在T2DM并发胆石症组发病率达71%。多因素Logistic回归分析,病程、合并OSAS、Hb A1c、高血脂、HOMA-IR、AHI是T2DM并发胆石症发病的高危因素。结论 OSAS发病率在T2DM并发胆石症患者中明显升高,OSAS与T2DM并发胆石症相关。
[Abstract]:Objective to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and type 2 diabetes mellitus (T2DM) complicated with cholelithiasis. Methods OSAS screening was performed on T2DM inpatients with T2DM from January to December 2015. According to the results of upper abdomen B ultrasound or CT, cholelithiasis was divided into two groups. The sex, age and course of disease were observed in the two groups. Combined with OSAS, HbA1cX, HbA1cX, hyperlipidemia, hyperlipidemia, Insulin resistance index (HOMA-IRN), sleep apnea times per hour, apnea and hypopnea times per hour in patients with obstructive sleep apnea syndrome (OSAS), apnea and hypopnea per hour, and minimum pulse volume oxygen saturation (LSp O _ 2) in patients with obstructive sleep apnea syndrome (OSAS). The difference of respiratory disorder index (RDI), To analyze the effect of OSAS on cholelithiasis in T2DM. Results the incidence of OSAS in T2DM complicated with cholelithiasis was 71%. Multivariate logistic regression analysis, course of disease, combined with OSASS-HbA1c, hyperlipidemia and HOMA-IRAHI were high risk factors for T2DM complicated with cholelithiasis. Conclusion the incidence of OSAS in patients with T2DM complicated with cholelithiasis is significantly higher than that in T2DM complicated with cholelithiasis.
【作者单位】：广东省湛江市第二人民医院内分泌科;
【分类号】：R587.2;R766;R575.62

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