变应性鼻炎患者血清中胸腺调节趋化因子及嗜酸性粒细胞趋化因子-2表达与临床意义

发布时间：2018-06-23 03:04

本文选题：鼻炎 + 变应性　；参考：《中国耳鼻咽喉头颈外科》2012年01期

【摘要】：目的探讨胸腺调节趋化因子(thymus andactivation regulated chemokine,TARC)及嗜酸性粒细胞趋化因子-2(Eotaxin-2)在变应性鼻炎(AR)患者血清中的表达水平及其在AR发病机制中的作用及临床意义。方法应用酶联免疫吸附实验法检测64例AR患者和16例非变应性鼻炎(non-allergic rhinitis,NAR)患者外周血中TARC及Eotaxin-2水平。结果①AR患者血清中TARC及Eotaxin-2光密度(optical density,OD)均值分别为0.476±0.038、2.661±0.902,与NAR组比较OD均值为0.425±0.030、1.055±0.33,差异有统计学意义(t=5.309、2.731,P0.05)。②轻度持续性AR患者与中重度持续性AR患者血清中TARC OD均值分别为0.450±0.035、0.490±0.015,两组比较,差异无统计学意义(t=1.500,P=0.011),而与NAR组比较,差异有统计学意义(t=2.100、3.080,P=0.010)。③轻度持续性AR患者与中重度持续性AR患者血清中Eotaxin-2 OD均值分别为2.660±0.900、3.13±1.375,两组比较,差异无统计学意义(t=1.618,P=0.032),而与NAR组比较,差异有统计学意义(t=6.874、5.900,P=0.034)。④AR患者血清中TARC与Eotaxin-2表达呈明显正相关(r=0.880,P0.01)。结论 TARC及Eotaxin-2在轻度持续性AR及中重度持续性AR患者血清中明显升高,二者呈正相关,可能因TH2反应导致AR的发生,但其增高水平与临床症状严重程度无明显相关性。
[Abstract]:Objective to investigate the expression of thymus regulatory chemokine (thymus andactivation regulated chemokine) and eotaxin-2 (eotaxin-2) in the serum of patients with allergic rhinitis (AR) and its role in the pathogenesis of AR and its clinical significance. Methods Enzyme-linked immunosorbent assay (Elisa) was used to detect the levels of TARC and eotaxin-2 in peripheral blood of 64 patients with AR and 16 patients with non-allergic rhinitis NAR. Results 1the OD values of TARC and eotaxin-2 optical density in patients with AR were 0.476 卤0.038 卤2.661 卤0.902, 0.425 卤0.030 卤1.055 卤0.33, respectively. The difference was statistically significant (t 5.309 卤2.731P0.05). 2 the mean value of serum OD of patients with mild persistent AR and moderate and severe persistent AR was 0.450 卤0.0350.490 卤0.015, respectively. There was no significant difference between the two groups (t = 1.500), but there was a significant difference compared with the NAR group (t = 2.100 / 3.080). 3 the mean value of eotaxin-2 OD _ 2 in patients with mild persistent AR and moderate and severe persistent AR was 2.660 卤0.900 ~ 3.13 卤1.375, respectively. There was no significant difference between the two groups (t1.618p _ (0.032), but there was no significant difference between the two groups (t _ (1.618) P _ (0.032), and the mean value of eotaxin-2 in patients with moderate and severe persistent AR was 2.660 卤0.900 ~ 3.13 卤1.375, respectively. There was a significant positive correlation between the expression of TARC and Eotaxin-2 in patients with AR (r = 0.880, P 0.01). Conclusion TARC and Eotaxin-2 were significantly increased in patients with mild persistent AR and moderate and severe persistent AR. There was a positive correlation between TARC and Eotaxin-2, which might be caused by TH2 reaction, but there was no significant correlation between the elevated level of TARC and Eotaxin-2 and the severity of clinical symptoms.
【作者单位】：吉林大学第二医院耳鼻咽喉头颈外科;青岛大学医学院附属烟台毓璜顶医院耳鼻咽喉头颈外科;吉林大学中日联谊医院耳鼻咽喉头颈外科;
【分类号】：R765.21

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