间充质干细胞对自身免疫性干眼的免疫调控作用研究进展

发布时间：2018-06-23 23:39

本文选题：间充质干细胞 + 自身免疫性干眼　；参考：《眼科新进展》2017年05期

【摘要】：间充质干细胞(mesonchymal stem cells,MSCs)具有良好的免疫调节功能,可以抑制多种免疫细胞群增殖,直接作用抑制T淋巴细胞的活化增殖,上调Treg细胞或通过分泌可溶性因子调节Th1/Th2反应平衡而发挥免疫调节作用,通过抗炎、调控各类性细胞因子的表达等方面抑制炎性因子的分泌同时促进抑炎因子分泌,降低基质金属蛋白酶2(MMP-2)、MMP-9等可能促进泪腺组织损害因子的表达水平,进而发挥其免疫调节作用,MSCs能减轻自身免疫性干眼的临床指标,恢复部分泪腺组织的分泌功能,本文就MSCs对自身免疫性干眼免疫调控的研究进展进行综述。
[Abstract]:Mesenchymal stem cells (mesonchymal stem cells) have a good immunomodulation function, which can inhibit the proliferation of various immune cell groups and directly inhibit the activation and proliferation of T lymphocytes. By up-regulating Treg cells or regulating Th1 / Th2 response balance by secreting soluble factors, inhibiting the secretion of inflammatory factors and promoting the secretion of anti-inflammatory factors through anti-inflammation, regulating the expression of various cytokines, etc. The decrease of matrix metalloproteinase 2 (MMP-2) and MMP-9 may promote the expression of lacrimal tissue damage factor, and then exert its immunomodulatory effect. MSCs can reduce the clinical indexes of autoimmune dry eye and restore the secretion function of some lacrimal gland tissues. This article reviews the progress in the regulation of autoimmune dry eye immunity by MSCs.
【作者单位】：天津北辰医院眼科;天津医科大学眼科医院眼视光学院;
【基金】：国家自然科学基金资助(编号:81100646) 天津市科委自然科学基金资助(编号:11JCYBJC26000、13JCYBJC23300) 教育部留学回国人员科研启动基金资助项目(第48批) 天津市北辰区科技发展计划项目(编号:BC2014-10)~~
【分类号】：R777.34

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