玻璃体腔内注射康柏西普联合玻璃体切除术治疗增殖性糖尿病视网膜病变的临床效果

发布时间：2018-06-28 14:55

本文选题：康柏西普 + 玻璃体腔内注射　；参考：《海峡药学》2016年09期

【摘要】：目的观察玻璃体腔内注射康柏西普联合玻璃体切除术治疗增殖性糖尿病视网膜病变(PDR)的临床效果。方法将临床确诊为PDR的患者79例79眼纳入本研究。依据术前是否行玻璃体腔内注射康柏西普将患者分为试验组和对照组:试验组40例40眼、对照组39例39眼。试验组术前3d玻璃体腔内注射康柏西普0.05m L(0.5mg),然后行玻璃体切割术,对照组直接行玻璃体切割术,术后随访12个月。比较两组术后视力、平均手术时间、术后眼压、术后并发症。结果试验组较对照组术后视力明显提高,分别为0.25±0.18和0.15±0.12,有统计学意义(P0.05)。平均手术时间试验组为25.26±10.31min,而对照组为41.12±13.54min(P0.05)。试验组术后3d眼压0眼升高,而对照组眼压Tn+1为5眼,占12.8%(P0.05),术后随访期内,试验组发生牵拉性视网膜脱离行再次手术后视网膜复位为1眼,而对照组再出血8眼,其中4眼出现牵拉性视网膜脱离需要再手术。结论增殖性糖尿病视网膜病变的患者,术前玻璃体腔注射0.5mg康柏西普可以显著提高视力,缩短手术时间,减少术后并发症的发生率,而对术后腿压的影响不大。
[Abstract]:Objective to observe the clinical effect of intravitreous injection of Compactopril combined with vitrectomy in the treatment of proliferative diabetic retinopathy (PDR). Methods 79 cases (79 eyes) with PDR were included in this study. Patients were divided into experimental group (40 eyes) and control group (39 eyes). The experimental group was treated with intravitreous injection of Combortopril 0.05m L (0.5mg) 3 days before operation, then vitrectomy was performed, and the control group was followed up for 12 months. Postoperative visual acuity, mean operative time, intraocular pressure and postoperative complications were compared between the two groups. Results the visual acuity of the experimental group was 0.25 卤0.18 and 0.15 卤0.12, respectively, which was significantly higher than that of the control group (P0.05). The mean operative time was 25.26 卤10.31 min in the experimental group and 41.12 卤13.54min in the control group (P0.05). The intraocular pressure (IOP) was increased in 0 eyes of the experimental group 3 days after operation, while that of the control group was 5 eyes (12. 8%). During the follow-up period, 1 eye was reattached after reoperation and 8 eyes in the control group. Reoperation was needed in 4 eyes with traction retinal detachment. Conclusion in patients with proliferative diabetic retinopathy, intravitreal injection of 0.5mg can significantly improve visual acuity, shorten operative time and reduce the incidence of postoperative complications, but has little effect on postoperative leg pressure.
【作者单位】：牡丹江医学院红旗医院院部眼科;
【分类号】：R779.6;R587.2

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