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复方苦参注射液联合放化疗治疗鼻咽癌疗效及安全性的Meta分析

发布时间:2018-06-28 13:39

  本文选题:复方苦参注射液 + 鼻咽癌 ; 参考:《中南医学科学杂志》2016年06期


【摘要】:目的系统评价复方苦参注射液辅助放化疗治疗鼻咽癌的有效性和安全性,为临床治疗提供循证参考。方法计算机检索The Cochrane Library、Medline、EMbase、CBM、CNKI、VIP、万方数据库,收集复方苦参注射液联合放化疗(试验组)对照单纯放化疗(对照组)治疗鼻咽癌的随机对照试验(RCTs),提取资料并评价质量后,采用Rev Man 5.3统计软件对完全缓解率、Ⅲ~Ⅳ级口腔黏膜炎发生率、Ⅲ~Ⅳ级放射性皮炎发生率、Ⅲ~Ⅳ级白细胞减少发生率进行Meta分析。结果共纳入7项RCT,合计328例患者。Meta分析结果显示,观察组患者治疗完全缓解率[OR=2.00,95%CI(1.27,3.13),P0.05]、Ⅲ~Ⅳ级口腔黏膜炎发生率[OR=0.35,95%CI(0.24,0.51),P0.05]、Ⅲ~Ⅳ级放射性皮炎发生率[OR=0.39,95%CI(0.25,0.60),P0.05]、Ⅲ~Ⅳ级白细胞减少发生率[OR=0.41,95%CI(0.28,0.58),P0.05]显著优于对照组,两组比较差异均有统计学意义。结论复方苦参注射液辅助放化疗治疗鼻咽癌疗效与安全性均更好。受纳入研究方法学的局限性,该结论有待更多高质量、大样本、长期随访的RCTs进一步验证。
[Abstract]:Objective to evaluate the efficacy and safety of compound Sophora flavescens injection in the treatment of nasopharyngeal carcinoma (NPC). Methods the Cochrane Library Medline was searched by computer, and the database of compound Sophora flavescens injection combined with radiotherapy and chemotherapy (trial group) was collected. The RCTs were collected from RCTs for nasopharyngeal carcinoma (NPC) treatment. The data were extracted and the quality was evaluated. The complete remission rate, the incidence of oral mucositis in grade 鈪,

本文编号:2078166

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