口炎清颗粒联合西帕依固龈液治疗鼻咽癌放射性口腔黏膜炎的疗效观察

发布时间：2018-06-29 15:36

本文选题：口炎清颗粒 + 西帕依固龈液　；参考：《现代药物与临床》2016年08期

【摘要】：目的探讨口炎清颗粒联合西帕依固龈液治疗鼻咽癌放射性口腔黏膜炎的临床疗效。方法选取2014年1月—2015年10月在湖北医药学院附属东风医院肿瘤科收治的鼻咽癌放射性口腔黏膜炎患者65例,随机分为对照组(33例)和治疗组(32例)。对照组给予西帕依固龈液,3~5 m L含漱3 min,5次/d;治疗组对照组治疗基础上口服口炎清颗粒,20 g溶于200 m L温开水冲服,2次/d,直至放疗结束。观察两组患者治疗前后疼痛程度和口腔黏膜分级的变化情况。结果治疗6、7周末,治疗组数字疼痛评分法(NRS)疼痛分级1级患者例数明显多于对照组,2~3级疼痛患者例数明显低于对照组,两组比较差异有统计学意义(P0.05)。治疗组在治疗4~7周末口腔黏膜分级1级患者例数显著多于对照组,3~4级患者例数明显低于对照组,两组比较差异有统计学意义(P0.05)。结论口炎清颗粒联合西帕依固龈液治疗鼻咽癌放射性口腔黏膜炎具有较好的临床疗效,可有效降低放射性口腔黏膜损伤及疼痛程度,具有一定的临床推广应用价值。
[Abstract]:Objective to investigate the clinical effect of oral clear granule combined with sipanil gingival fluid in the treatment of nasopharyngeal carcinoma radioactive oral mucositis. Methods Sixty-five patients with radioactive oral mucositis of nasopharyngeal carcinoma treated in Dongfeng Hospital affiliated to Hubei Medical College from January 2014 to October 2015 were randomly divided into control group (33 cases) and treatment group (32 cases). The control group was treated with sipanil gums for 3 min and 5 times / d, and the control group was given orally oral stomatitis clear granule 20 g dissolved in 200 mL warm boiled water for 2 times / d until the end of radiotherapy. The changes of pain degree and oral mucosal grade before and after treatment were observed. Results at the end of 6 ~ 7 weeks, the number of patients with NRS pain grade 1 in the treatment group was significantly higher than that in the control group (P 0.05). The number of patients with pain grade 2 or 3 in the control group was significantly lower than that in the control group (P0.05). The number of patients with oral mucosal grade 1 was significantly higher in the treatment group than that in the control group at the end of 4 weeks. The difference between the two groups was statistically significant (P0.05). Conclusion the oral cavity mucositis of nasopharyngeal carcinoma treated by oral mucositis treated by oral granule combined with sipanil has a good clinical effect, and can effectively reduce the degree of injury and pain of radioactive oral mucosa. It has a certain clinical value in popularizing and applying.
【作者单位】：湖北医药学院附属东风医院肿瘤科;
【分类号】：R739.63;R781.5

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