TGF-β在角膜损伤修复中的时间和空间分布

发布时间：2018-06-30 03:12

本文选题：角膜损伤修复 + 转化生长因子-β　；参考：《眼科新进展》2017年02期

【摘要】：角膜损伤后的纤维化修复是角膜瘢痕形成的主要原因。转化生长因子-β(transforming growth factor-beta,TGF-β)在角膜的稳态平衡中起着至关重要的作用,是角膜损伤修复的重要参与者。同时,角膜上皮基底膜是角膜创伤修复过程中角膜上皮与基质相互作用的重要屏障。角膜损伤修复的不同阶段,各亚型TGF-β在角膜各种细胞及各个不同部位存在着分布差异,角膜上皮基底膜是否完整是影响该过程的重要因素。TGF-β不同亚型在时间和空间上的分布差异及变化与角膜的创伤修复过程中细胞的迁移、增殖、表型变化及细胞外基质沉着都紧密相关,是瘢痕愈合及无瘢痕愈合的细胞分子生物学基础。本文就TGF-β的生物学功能及其亚型在角膜损伤修复中的时间和空间分布情况作一综述。
[Abstract]:The repair of corneal fibrosis after corneal injury is the main cause of corneal scar formation. Transforming growth factor- 尾 (transforming growth factor-beta- 尾 (TGF- 尾) plays an important role in the homeostasis of cornea and plays an important role in corneal injury repair. At the same time, corneal epithelial basement membrane is an important barrier to the interaction between corneal epithelium and stroma during corneal wound repair. In different stages of corneal injury repair, the distribution of TGF- 尾 was different in various corneal cells and different parts of cornea. Whether the corneal epithelial basement membrane is intact or not is an important factor affecting the process. The time and space distribution of different subtypes of TGF- 尾 and the changes of the corneal epithelial basement membrane are related to the migration and proliferation of the cells in the process of corneal wound repair. Phenotypic changes and extracellular matrix deposition are closely related, which is the cellular molecular biological basis of scar healing and scarless healing. This paper reviews the biological function of TGF- 尾 and the temporal and spatial distribution of TGF- 尾 subtypes in corneal injury repair.
【作者单位】：广西医科大学第一附属医院眼科;
【基金】：国家自然科学基金资助(编号:81060076;81360144)~~
【分类号】：R772.2

【参考文献】