益生菌对化脓性扁桃腺炎治疗后发生抗生素相关性腹泻的影响

发布时间：2018-06-30 05:00

  本文选题：化脓性扁桃体炎 + 抗生素相关性腹泻　； 参考：《中国现代医学杂志》2016年05期

【摘要】：目的观察益生菌对抗生素治疗化脓性扁桃体炎所继发抗生素相关性腹泻(AAD)是否有预防作用。方法选择郑州市儿童医院门急诊使用广谱抗生素治疗537例化脓性扁桃体炎患儿。其中353例完成研究,将该353例化脓性扁桃体炎患儿随机分为干预组和对照组,干预组在抗生素治疗第1天加用益生菌,抗生素停止后继续应用3 d,观察组仅用抗生素,观察其出现AAD时间及数量。结果两组患儿入组前后抗生素使用种类、途径及时间比较,差异无统计学意义,治疗随访结束时,干预组累计有22例发生AAD,发生率为11.17%,显著低于对照组的23.08%(χ~2=8.993,P=0.003),两者比较差异有统计学意义(P0.01),且ADD发生时间明显后移。危险度分析显示,相对于对照组,应用益生菌治疗后AAD发生风险降低58.1%。且腹泻发生时间除第1天外各组间比较差异有统计学意义(P0.05)。在整个治疗观察期间无益生菌相关不良反应。结论益生菌可以减低化脓性扁桃体炎抗生素治疗后AAD的发生,化脓性扁桃体炎患儿加用益生菌治疗是有益的。未发现其不良反应。
[Abstract]:Objective to observe the preventive effect of probiotics on antibiotic associated diarrhea (AAD) secondary to suppurative tonsillitis. Methods 537 children with suppurative tonsillitis were treated with broad-spectrum antibiotics in outpatient and emergency department of Zhengzhou Children's Hospital. 353 children with suppurative tonsillitis were randomly divided into the intervention group and the control group. The intervention group was treated with probiotics on the first day of antibiotic treatment. The time and quantity of AAD were observed. Results there was no significant difference in the use of antibiotics between the two groups before and after entering the group, and there was no significant difference between the two groups. In the intervention group, 22 cases (11.17%) developed AAD, which was significantly lower than that in the control group (23.08%) (蠂 ~ (2 / 2) ~ (8.993) P ~ (0.003). The difference between the two groups was statistically significant (P0.01), and the onset time of add was obviously shifted back. Risk analysis showed that compared with the control group, the risk of AAD was reduced by 58.1% after probiotics therapy. Besides the first day, there were significant differences in the time of diarrhea (P0.05). There were no probiotic related adverse reactions during the treatment observation period. Conclusion probiotics can reduce the incidence of AAD in children with suppurative tonsillitis after antibiotic therapy, and it is beneficial to treat children with suppurative tonsillitis with probiotics. No adverse reactions were found.
【作者单位】： 河南省郑州市儿童医院急诊科;河南省郑州市儿童医院心电图室;
【分类号】：R766.18
，

本文编号：2085006