雾化吸入布地奈德可降低鼻咽癌调强放疗致鼻口等相关并发症发生率

发布时间：2018-07-03 14:38

本文选题：鼻咽癌 + 调强放疗　；参考：《基因组学与应用生物学》2017年06期

【摘要】：为探讨雾化吸入布地奈德对鼻咽癌调强放疗致鼻口等相关并发症的防治作用,用随机数字法将行调强放疗治疗的80例鼻咽癌患者分为观察组与对照组,各40例,观察组放疗期间给予布地奈德雾化吸入干预,对照组常规生理盐水干预,比较两组放疗前后气导听阈变化、放疗后鼻咽粘膜反应程度、不同放射剂量III度黏膜损伤情况及相关并发症发生率。观察组放疗结束后语言频区平均气导听阈值显著低于对照组(p0.05);观察组放疗结束后鼻咽黏膜反应程度显著轻于对照组(p0.05);观察组放疗剂量31~50 Gy、51~70 Gy时3度黏膜损伤发生率均显著低于对照组(p0.05);观察组中耳炎、副鼻窦炎、鼻腔粘连、后鼻孔狭窄及咽喉干燥感发生率分别为27.50%、57.50%、15.00%、10.00%、22.50%,均显著低于对照组的50.00%、87.50%、37.50%、30.00%、75.00%,差异有统计学意义(p0.05)。鼻咽癌调强放疗治疗期间给予布地奈德雾化吸入干预能明显减轻患者鼻咽黏膜损伤程度,有效减少鼻咽口相关并发症发生。
[Abstract]:In order to investigate the effect of nebulization inhalation of budesonide on the prevention and treatment of nasal and oral complications caused by nasopharyngeal carcinoma, 80 cases of nasopharyngeal carcinoma were divided into observation group and control group, 40 cases in each group, each of the observation group was given budesonide inhalation intervention during the radiotherapy, and the control group was compared with normal saline intervention. The changes of air conduction hearing threshold before and after radiotherapy, the degree of nasopharyngeal mucosa reaction after radiotherapy, III degree of mucosal injury with different radiation dose and incidence of complications. The average air conduction threshold in the language frequency area of the observation group was significantly lower than that of the control group (P0.05) after the end of radiotherapy (III). The degree of nasopharyngeal mucosa reaction in the observation group was significantly lighter than that of the control group after the radiotherapy. (P0.05); the incidence of 3 degrees of mucosal damage at the dose of 31~50 Gy in the observation group was significantly lower than that in the control group (P0.05). The incidence of otitis media, paranasal sinusitis, nasal adhesion, posterior nostral stenosis and sore throat desiccation were 27.50%, 57.50%, 15%, 10%, 22.50%, respectively, and were significantly lower than those of the control group of 50%, 87.50%, 37.50%, 30%, 75%. The difference was statistically significant (P0.05). The intervention of budesonide inhalation during the treatment of nasopharyngeal carcinoma could significantly reduce the degree of nasopharyngeal mucosa injury and reduce the incidence of nasopharyngeal related complications.
【作者单位】：云南省第一人民医院;
【基金】：云南省厅级项目(2010W-11-3-007-03)资助
【分类号】：R739.63

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