丹溪玉屏风颗粒联合纳他霉素治疗真菌性角膜炎的临床效果观察

发布时间：2018-07-03 14:55

本文选题：丹溪玉屏风颗粒 + 纳他霉素　；参考：《中药药理与临床》2016年05期

【摘要】：目的:观察丹溪玉屏风颗粒联合纳他霉素治疗真菌性角膜炎的临床效果。方法:纳入我院眼科2014年1月至2015年4月收治的真菌性角膜炎患者80例,随机双盲地将患者分为观察组和对照组各40例,对照组给予纳他霉素治疗,观察组给予丹溪玉屏风颗粒联合纳他霉素治疗。记录治疗前患者相关指标,并对治疗后两组患者相关指标进行对比分析。结果:观察组患者治疗后视力指数和角膜溃疡直径分别为(0.45±0.04、1.90±0.21mm),均明显优于对照组(0.38±0.03、2.68±0.30mm)。观察组患者治疗后角膜溃疡消失时间、前房积脓消失时间、畏光流泪消失时间和异物感消失时间分别为(15.46±2.08、14.92±2.16、18.38±2.01、14.93±1.94)d,均明显优于对照组(20.96±3.46、19.86±3.82、22.73±3.01、18.84±2.93)d。3治疗后观察组患者TNF-α和IL-1β水平分别为(11.35±3.01、10.28±2.11)pg/ml,明显显著低于对照组(19.83±4.02、17.42±2.95)pg/ml。4观察组治疗后总有效率为95.00%,显著高于对照组75.00%。5观察组患者治疗后转阴率为60.00%,显著高于对照组35.00%。6治疗后观察组菌种数为23株,显著少于对照组42株。结论:丹溪玉屏风颗粒联合纳他霉素治疗真菌性角膜炎的疗效优于单独运用纳他霉素,且无明显副作用。
[Abstract]:Objective: to observe the clinical effect of Danxi Yupingfeng granule combined with natamycin in the treatment of fungal keratitis. Methods: 80 patients with fungal keratitis admitted to our hospital from January 2014 to April 2015 were randomly divided into observation group (n = 40) and control group (n = 40). The control group was treated with natamycin. The observation group was treated with Danxi Yupingfeng granule combined with natamycin. The relative indexes of patients before treatment were recorded and compared between the two groups after treatment. Results: after treatment, the visual acuity index and corneal ulcer diameter in the observation group were (0.45 卤0.04) and 1.90 卤0.21mm, respectively, which were significantly better than those in the control group (0.38 卤0.03 卤2.68 卤0.30mm). In the observation group, the corneal ulcer disappeared and the anterior chamber empyema disappeared after treatment. The time of disappearance of photophobia and foreign body sensation were (15.46 卤2.08t 14.92 卤2.16v 18.38 卤2.01v 14.93 卤1.94) days, respectively, which were significantly better than those of the control group (20.96 卤3.4219.86 卤3.821,22.73 卤3.01n 18.84 卤2.93) d.3, respectively. The levels of TNF- 伪 and IL-1 尾 were (11.35 卤3.01) 10.28 卤2.11 PG / ml, which was significantly lower than that of the control group (19.83 卤4.0217.42 卤2.95). The total effective rate of TNF- 伪 and IL-1 尾 in the observation group was (11.35 卤3.01) 卤10.28 卤2.11, which was significantly lower than that in the control group (19.83 卤4.0217.42 卤2.95). Compared with the control group 75.00.5, the negative rate of the observation group was 60.005, significantly higher than that of the control group 35.00.6 after treatment, the number of bacteria in the observation group was 23. It was significantly less than the control group (42 strains). Conclusion: Danxi Yupingfeng granule combined with natamycin is more effective than natamycin alone in the treatment of fungal keratitis.
【作者单位】：内蒙古医科大学中医学院;郑州大学附属郑州中心医院;
【分类号】：R772.21

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