普拉洛芬滴眼液不同用药时间对干眼症疗效的影响

发布时间：2018-07-14 09:47

【摘要】：目的探讨普拉洛芬滴眼液不同用药时间对干眼症疗效的影响。方法选取我院眼科门诊诊断为双眼干眼症的患者117例,按照随机数字表法将患者分成普拉洛芬14 d组(39例)、普拉洛芬30 d组(40例)和对照组(38例)。普拉洛芬14 d组给予1 g·L~(-1)普拉洛芬滴眼液(14 d)联合1 g·L~(-1)玻璃酸钠滴眼液(30 d);普拉洛芬30 d组给予1 g·L~(-1)普拉洛芬滴眼液(30 d)联合1 g·L~(-1)玻璃酸钠滴眼液(30 d),对照组仅给予1 g·L~(-1)玻璃酸钠滴眼液(30 d)。给药方法均为局部滴双眼,每次1滴,每天4次。分别于治疗前后检测3组患者的泪液分泌试验I(Schirmer I test,SIt)、泪膜破裂时间(tear break-up time,BUT)和角膜荧光素染色(corneal fluorescent staining,FL)评分。结果治疗前3组患者人口基线特征比较差异均无统计学意义(均为P0.05)。治疗后普拉洛芬14 d组SIt(7.11±1.36)mm和BUT(8.42±0.79)s均高于对照组SIt(5.19±0.85)mm和BUT(5.92±1.24)s;FL评分(0.73±0.72)显著低于对照组(1.88±0.71),差异均有统计学意义(tSIt=8.000,P0.001;tBUT=10.870,P0.001;tFL=-7.667,P0.001);治疗后普拉洛芬30 d组SIt(7.38±1.01)mm和BUT(8.12±1.00)s均高于对照组,FL评分(0.88±0.68)显著低于对照组,差异均有统计学意义(tSIt=9.125,P0.001;tBUT=9.565,P0.001;tFL=-6.667,P0.001);但治疗后普拉洛芬14 d组与普拉洛芬30 d组的SIt、BUT和FL评分差异均无统计学意义(tSIt=~(-1).125,0.4P0.2;tBUT=1.304,0.2P0.1;tFL=~(-1).000,0.4P0.2)。结论短期应用1 g·L~(-1)普拉洛芬滴眼液治疗干眼症即可达到较好的疗效,它是辅助治疗干眼症的有效药物。
[Abstract]:Objective to investigate the effect of Praprofen eye drops on dry eye. Methods 117 patients diagnosed as binocular xerophthalmia were randomly divided into three groups: Praprofen 14-day group (39 cases), Praprofen 30-day group (40 cases) and control group (38 cases). 1 g L ~ (-1) Praprofen eye drops (14 d) combined with 1 g L ~ (-1) sodium hyaluronate eye drops (30 d);) Praprofen eye drops (30 d) combined with 1 g L ~ (-1) sodium hyaluronate eye drops (30 d), control group) 1 g L ~ (-1) sodium hyaluronate eye drops (30 d).) The methods of administration were local drops of both eyes, 1 drop each time, 4 times a day. The tear secretion test I (Schirmer I test), tear break-up time of rupture (tear break-up timebut) and corneal fluorescein staining (corneal fluorescent staining) were measured before and after treatment. Results there was no significant difference in population baseline characteristics between the three groups before treatment (P0.05). 娌荤枟鍚庢櫘鎷夋礇鑺，

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