OSAHS伴胰岛素抵抗患者术后脂肪因子水平改变的研究

发布时间：2018-07-17 00:25

【摘要】：目的:探讨OSAHS伴胰岛素抵抗(IR)患者术后脂肪因子水平的改变与临床意义。方法:连续性纳入2015-01-2016-08期间就诊的84例OSAHS患者,根据IR情况分为IR组(52例)和非IR组(32例)。所有患者接受悬雍垂腭咽成形术(UPPP),并分别于术前、术后1周和3个月检测chemerin、visfatin和obestatin 3种脂肪因子的水平。结果:IR组患者术前chemerin、visfatin和稳态模型胰岛素抵抗指数(HOMA-IR)水平明显高于非IR组(P0.05),而obestatin水平明显低于非IR组(P0.05)。术后1周时IR组obestatin水平明显低于非IR组(P0.05),HOMA-IR明显高于非IR组(P0.05)。组内比较可见术后1周IR组患者chemerin、visfatin和HOMA-IR明显下降(P0.05),obestitin明显上升(P0.05)。UPPP术与△chemerin(r=-0.685,P0.05)和△HOMA-IR(r=-0.622,P0.05)呈负相关,与△obestitin呈正相关(r=0.612,P0.05)。△HOMA-IR与△chemerin呈正相关(r=0.634,P0.05)。结论:OSAHS患者经过手术治疗后,chemerin、visfatin和obestatin的水平和IR均明显改善,其中chemerin与IR改善情况最为相关。
[Abstract]:Objective: to investigate the changes and clinical significance of fat factor levels in OSAHS patients with insulin resistance (IR). Methods: 84 OSAHS patients who were admitted continuously from 2015-01-2016-08 were divided into IR group (n = 52) and non-IR group (n = 32) according to IR. All patients were treated with uvulopalatopharyngoplasty (UPPP), and the levels of chemininvisfatin and obestatin were measured before, 1 week and 3 months after operation. Results the levels of preoperative chemerininvisfatin and homeostasis model insulin resistance index (HOMA-IR) were significantly higher in the weight IR group than in the non-IR group (P0.05), but the level of obestatin was significantly lower than that in the non-IR group (P0.05). The level of obestatin in IR group was significantly lower than that in non-IR group (P0.05) and HOMA-IR was significantly higher than that in non-IR group at 1 week after operation (P0.05). One week after operation, the levels of chemerinine visfatin and HOMA-IR in IR group were significantly decreased (P0.05). (P0.05). There was a negative correlation between chemerin (r-0.685) and HOMA-IR (r-0.622), and a positive correlation between HOMA-IR and chemerin (rr 0.634 P 0.05). Conclusion the levels of visfatin and obestatin and IR in patients with OSAHS were significantly improved after surgical treatment, and the improvement of chemerin and IR was the most significant.
【作者单位】：常熟市中医院新区医院耳鼻咽喉科;
【分类号】：R766.9

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