眼表综合分析仪在评价干燥综合征干眼中的临床意义
发布时间：2018-07-23 15:32
【摘要】：目的探讨干燥综合征患者主观症状上的Mc Monnie问卷评分、眼科检查和免疫学相关检查等辅助检查在评价干燥综合征干眼中的临床意义。方法干燥综合征干眼患者共102例204眼,其中83人有效完成Mc Monnie问卷调查以评估主观症状;101人完成眼表综合分析仪等眼科相关检查,94人完成免疫球蛋白Ig G、Ig A、Ig M、补体C3、补体C4和C反应蛋白的检查,78人完成抗核抗体、抗α胞衬蛋白抗体、抗ENA抗体-SSA和抗ENA抗体-SSB的检查。采用t检验和卡方检验比较相关数据之间的联系。结果主观问卷评分与角膜荧光素染色结果(P=0.019)、脂质层颜色(P=0.027)有相关性。年龄与睑板腺数量有相关性(P=0.022)。双眼脂质层颜色(P=0.015)、角膜荧光素染色(P=0.025)和泪河高度(P=0.039)均与血清中Ig G水平存在相关性。血清中Ig A水平和BUT结果有相关性(P=0.022)。结论泪膜脂质层、睑板腺、角膜的结构和功能的状态与患者的眼部症状关系密切,血清中免疫球蛋白水平与其眼科客观检查的指标有明显关联,可作为干燥综合征干眼的整体病情和泪膜角膜损伤程度的重要评估手段。
[Abstract]:Objective to investigate the clinical significance of Mc Monnie questionnaire, ophthalmology and immunological examination in the evaluation of dry eyes of Sjogren's syndrome (Sjogren's syndrome). Methods 102 cases (204 eyes) of dry eye with Sjogren's syndrome, Among them, 83 patients completed the Mc Monnie questionnaire to evaluate subjective symptoms. 101 patients completed ophthalmological examination, such as ocular surface comprehensive analyzer. 94 patients completed immunoglobulin Ig Gluten Ig Ig M, complement C3, complement C4 and C-reactive protein examination. 78 patients completed anti-nuclear antibody. Detection of anti 伪 lining protein antibody, anti ENA antibody -SSA and anti ENA antibody-SSB. T test and chi-square test were used to compare the relationship between relevant data. Results the subjective questionnaire scores were correlated with corneal fluorescein staining (P0. 019) and lipid layer color (P0. 027). There was a correlation between age and the number of meibomian glands (P0. 022). The color of lipid layer in both eyes (P0. 015), corneal fluorescein staining (P0. 025) and lacrimal river height (P0. 039) were all correlated with serum Ig G level. The level of IgA in serum was correlated with the results of BUT (P0. 022). Conclusion the structure and function of lipid layer of tear film, meibomian gland and cornea are closely related to the ocular symptoms, and the level of immunoglobulin in serum is closely related to the objective examination of ophthalmology. It can be used as an important method to evaluate the whole condition of dry eye and the degree of tear film cornea injury in Sjogren's syndrome.
【作者单位】： 北京大学人民医院风湿免疫科;
【基金】：国家自然科学基金资助(编号:81373117、81429003) 首都临床特色应用研究(编号:Z131107002213060)~~
【分类号】：R593.2;R771.3
本文编号：2139847
[Abstract]:Objective to investigate the clinical significance of Mc Monnie questionnaire, ophthalmology and immunological examination in the evaluation of dry eyes of Sjogren's syndrome (Sjogren's syndrome). Methods 102 cases (204 eyes) of dry eye with Sjogren's syndrome, Among them, 83 patients completed the Mc Monnie questionnaire to evaluate subjective symptoms. 101 patients completed ophthalmological examination, such as ocular surface comprehensive analyzer. 94 patients completed immunoglobulin Ig Gluten Ig Ig M, complement C3, complement C4 and C-reactive protein examination. 78 patients completed anti-nuclear antibody. Detection of anti 伪 lining protein antibody, anti ENA antibody -SSA and anti ENA antibody-SSB. T test and chi-square test were used to compare the relationship between relevant data. Results the subjective questionnaire scores were correlated with corneal fluorescein staining (P0. 019) and lipid layer color (P0. 027). There was a correlation between age and the number of meibomian glands (P0. 022). The color of lipid layer in both eyes (P0. 015), corneal fluorescein staining (P0. 025) and lacrimal river height (P0. 039) were all correlated with serum Ig G level. The level of IgA in serum was correlated with the results of BUT (P0. 022). Conclusion the structure and function of lipid layer of tear film, meibomian gland and cornea are closely related to the ocular symptoms, and the level of immunoglobulin in serum is closely related to the objective examination of ophthalmology. It can be used as an important method to evaluate the whole condition of dry eye and the degree of tear film cornea injury in Sjogren's syndrome.
【作者单位】： 北京大学人民医院风湿免疫科;
【基金】：国家自然科学基金资助(编号:81373117、81429003) 首都临床特色应用研究(编号:Z131107002213060)~~
【分类号】：R593.2;R771.3
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1 霍丽君,廖瑞端,陈雪梅,黄静文,冯涓涓;干燥综合征与非干燥综合征干眼临床诊断的比较研究[J];中国实用眼科杂志;2005年04期
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