血小板活化因子及血小板四参数在糖尿病视网膜病变中的变化及临床意义

发布时间：2018-07-27 10:52

【摘要】：目的探讨血小板活化因子和血小板四参数在糖尿病视网膜病变(diabetic retinopathy,DR)中的关系。方法选取2015年1月至2015年12月于我院眼科就诊的糖尿病患者80例(160眼),行常规眼科检查、眼底荧光素血管造影检查等,依据国际临床DR分级标准,将患者分为3组:糖尿病无视网膜病变(单纯糖尿病)组20例,非增生型糖尿病视网膜病变(non-proliferative diabetic retinopathy,NPDR)组20例,增生型糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)组20例;同期门诊体检的健康人20人为正常对照组。测定血小板活化因子CD62p、CD63,血小板四参数:血小板计数(platelet count,PLT)、平均血小板体积(mean platelet volume,MPV)、血小板压积(plateletcrit,PCT)、血小板平均分布宽度(platelet distribution width,PDW),探讨血小板活化因子及血小板四参数在DR中的变化及其临床意义。结果 CD62p、CD63、MVP随着病情的进展逐渐增高,而PLT逐渐降低,各组间差异有统计学意义(P0.05)。与正常对照组相比,其他各组的CD62p、CD63和MVP增高,PLT降低,差异均有统计学意义(均为P0.05)。与单纯糖尿病组相比,NPDR组和PDR组的CD62p、CD63和MVP增高,PLT降低,差异均有统计学意义(均为P0.05)。与NPDR组相比,PDR组的CD62p、CD63和MVP增高,PLT降低,差异均有统计学意义(均为P0.05)。对照组、单纯糖尿病组、NPDR组和PDR组的PDW逐渐增高,与正常对照组或单纯糖尿病组相比,NPDR组和PDR组的PDW增大,差异均有统计学意义(均为P0.05)。PCT组间比较差异无统计学意义(P0.05)。结论血小板活化因子CD62p、CD63和血小板四参数在DR各期表现有所差异,血小板活化因子在DR的发生、发展过程中有重要的作用,对血小板活化因子及血小板四参数的检测有助于疾病的监控。
[Abstract]:Objective to investigate the relationship between platelet activating factor and platelet four parameters in diabetic retinopathy Dr. Methods from January 2015 to December 2015, 80 patients (160 eyes) with diabetes mellitus were selected for routine ophthalmic examination and fundus fluorescein angiography. The patients were divided into three groups: 20 patients with diabetic retinopathy, 20 patients with non-proliferative diabetic retinopathy and 20 patients with proliferative diabetic retinopathy (proliferative diabetic retinopathy). In the same period, 20 healthy persons were taken as the normal control group. Platelet activating factor (CD62pnc), platelet four parameters (platelet count, mean platelet volume (mean platelet volume MPV), platelet compression volume (PCT) and mean distribution width of platelet (platelet distribution widtht PDW) were measured. To investigate the role of platelet activating factor and platelet four parameters in Dr And its clinical significance. Results the MVP of CD62pncCD63mVP increased with the progression of the disease, but the PLT decreased gradually, the difference was statistically significant (P0.05). Compared with the control group, CD62pU CD63 and MVP in other groups were significantly lower than those in the control group (P0.05). Compared with the simple diabetes group, the CD62pNCD63 and MVP in the NPDR group and the PDR group were significantly lower than those in the control group (P0.05). Compared with the NPDR group, the CD62pU CD63 and MVP in the PDR group were significantly lower than those in the NPDR group (P0.05). The PDW of control group, simple diabetes group and PDR group increased gradually, compared with the normal control group or simple diabetes group, the PDW of PDR group increased, the difference was statistically significant (P0.05). There was no significant difference between PCT group and normal control group (P0.05). Conclusion Platelet-activating factor CD62pc63 and platelet four parameters are different in different stages of Dr. Platelet activating factor plays an important role in the pathogenesis and development of Dr. The detection of platelet activating factor and platelet four parameters is helpful for disease monitoring.
【作者单位】：石河子大学;
【分类号】：R587.2;R774.1

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