老年鼻息肉患者经鼻内镜术切除后组织嗜酸粒细胞和肿瘤坏死因子α表达与预后的关系

发布时间：2018-07-28 19:42

【摘要】：目的探讨老年鼻息肉患者经鼻内镜术切除后组织嗜酸粒细胞和肿瘤坏死因子(TNF)-α表达与预后的关系。方法回顾性分析行鼻内镜术切除老年鼻息肉患者40例,以手术6个月内术腔完全上皮化和未完全上皮化的患者分为预后好组22例和预后差组18例。分别应用免疫组织化学和苏木精-伊红染色的方法,研究两组鼻息肉组织中嗜酸粒细胞和IFN-α的表达,采用Logistic回归分析法分析老年鼻息肉患者经鼻内镜术切除后预后与组织嗜酸粒细胞与TNF-α的关系。结果预后好组鼻息肉组织中嗜酸粒细胞的表达较预后差组弱(P0.05);两组鼻息肉组织中TNF-α的主要细胞有固有浸润细胞、血管内皮细胞、腺体细胞,均定位于细胞质。在预后好组鼻息肉组织中,TNF-α的表达较预后差组弱(P0.05);有较多的炎症细胞浸润于鼻息肉组织的固有层,其中预后差组的嗜酸粒细胞TNF-α表达的总阳性率显著高于预后好组(P0.01),Logistic回归分析显示,组织中嗜酸粒细胞与TNF-α是影响老年鼻息肉患者经鼻内镜术切除后预后的重要因素(P0.05)。结论嗜酸粒细胞与TNF-α在鼻息肉组织中呈高表达状态,且影响老年鼻息肉鼻内镜切除术预后效果。
[Abstract]:Objective to investigate the relationship between the expression of eosinophil, tumor necrosis factor (TNF)-伪 and prognosis in elderly patients with nasal polyps after endoscopic resection. Methods 40 elderly patients with nasal polyps underwent endoscopic resection were retrospectively analyzed. The patients with complete epithelization and incomplete epithelization were divided into good prognosis group (22 cases) and poor prognosis group (18 cases). The expression of eosinophils and IFN- 伪 in nasal polyps was studied by immunohistochemistry and hematoxylin-eosin staining. The relationship between prognosis, tissue eosinophil and TNF- 伪 in elderly patients with nasal polyps was analyzed by Logistic regression analysis. Results the expression of eosinophil in nasal polyps with good prognosis was weaker than that in poor prognosis group (P0.05), and the main cells of TNF- 伪 in nasal polyp tissues were intrinsically infiltrated cells, vascular endothelial cells and glandular cells, which were located in cytoplasm. The expression of TNF- 伪 in nasal polyps with good prognosis was weaker than that with poor prognosis (P0.05), and more inflammatory cells infiltrated the lamina propria of nasal polyps. The positive rate of TNF- 伪 expression in the poor prognosis group was significantly higher than that in the good prognosis group (P0.01) logistic regression analysis showed that eosinophils and TNF- 伪 were the important factors influencing the prognosis of the elderly patients with nasal polyp after endoscopic resection (P0.05). Conclusion the expression of eosinophil and TNF- 伪 in nasal polyps is high, and it affects the prognosis of nasal endoscopic resection of nasal polyps in the elderly.
【作者单位】： 海南医学院第二附属医院耳鼻咽喉头颈外科;
【分类号】：R765.9

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