赛洛唑啉滴鼻液在局部麻醉鼻内镜手术中的应用研究

发布时间：2018-08-03 16:37

【摘要】：目的探讨赛洛唑啉滴鼻液在局部麻醉鼻内镜手术中的应用价值。方法行局部麻醉鼻内镜手术的患者分为赛洛唑啉组和肾上腺素组,每组60例。观察两组患者术中出现鼻腔黏膜反跳性充血水肿的情况、鼻腔疼痛的情况、术中出血量、术中血压和心率变化。结果肾上腺素组(9/60)较赛洛唑啉组(0/60)术中更易出现鼻腔黏膜反跳性充血水肿(P0.05)。肾上腺素组(9/60)较赛洛唑啉组(1/60)术中更易出现鼻腔疼痛(P0.05)。术中平均出血量比较,肾上腺素组(259±48)mL与赛洛唑啉组(282±36)mL差异无统计学意义(P0.05)。术中各时间点血压、心率相比,肾上腺素组与赛洛唑啉组差异无统计学意义(P0.05)。肾上腺素组(7/60)较赛洛唑啉组(1/60)术中更易出现不良的心血管反应,差异有统计学意义(P0.05)。结论赛洛唑啉作为局部麻醉鼻内镜手术的减充血剂,不易出现鼻腔黏膜反跳性充血水肿及不良的心血管反应,较肾上腺素更安全,值得在临床上推广应用。
[Abstract]:Objective to evaluate the clinical value of ciloxoline nasal drops in endoscopic surgery under local anesthesia. Methods patients undergoing nasal endoscopic surgery under local anesthesia were divided into two groups: ciloxaline group and epinephrine group with 60 cases in each group. The changes of nasal mucosa reversion hyperemia edema, nasal pain, intraoperative blood loss, blood pressure and heart rate were observed in both groups. Results in epinephrine group (9 / 60), nasal mucosal bouncing hyperemia and edema were more likely to occur during the operation (P0.05) than that in cylozoline group (0 / 60). Nasal pain was more likely in adrenaline group (9 / 60) than in ciloxaline group (1 / 60) (P0.05). There was no significant difference between epinephrine group (259 卤48) mL and sellozoline group (282 卤36) mL (P0.05). There was no significant difference in blood pressure and heart rate between epinephrine group and sellozoline group (P0.05). Adverse cardiovascular reactions were more likely in adrenaline group (7 / 60) than in ciloxaline group (1 / 60) (P0.05). Conclusion Cylozoline as a hyperemia reducing agent for local anesthesia nasal endoscopic surgery is not easy to appear nasal mucosa bouncing hyperemia edema and adverse cardiovascular reaction which is more safe than adrenaline. It is worth popularizing in clinic.
【作者单位】：重庆市红十字会医院(江北区人民医院)耳鼻咽喉科;重庆医科大学附属第一医院耳鼻咽喉头颈外科;
【分类号】：R765.9

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