POAG患者习惯性体位眼压及眼灌注压昼夜波动趋势的研究

发布时间：2018-08-15 15:15

【摘要】：目的:探讨初诊未行治疗的原发性开角型青光眼(primary open angle glaucoma,POAG)患者习惯性体位眼压及眼灌注压(ocular perfusion pressure,OPP)波动趋势,并验证由日间平均坐位及卧位眼压推导夜间峰值眼压的可行性。方法:选取POAG患者19例19眼及正常对照组18例18眼,分别于10∶00,14∶00,18∶00及22∶00时行坐位眼压及血压监测,为验证由日间卧位眼压推导夜间峰值眼压的可行性,另对POAG组于卧位5min后再行监测。2∶00,5∶00及7∶00行卧位监测,计算出OPP并行数据分析。由已知公式通过日间眼压计算夜间峰值眼压,并与实际值对比。结果:24h习惯性体位下,POAG患者平均眼压及眼压波动均高于正常对照组(P0.05),POAG组平均眼压峰值出现于凌晨5∶00,对照组则为7∶00。两组夜间眼压均值均大于日间,差异有统计学意义(P0.05)。两组内习惯性体位平均眼灌注压(MOPP)均表现为夜间低于日间(P0.05),而两组间MOPP无明显统计学差异(P0.05)。POAG患者MOPP波动较对照组大,差异有统计学意义(P0.05)。由两公式推导所得夜间眼压峰值均与所测值无明显统计学差异(P0.05)。结论:习惯性体位下POAG组及正常人的眼压峰值多出现在凌晨至上午,POAG患者的习惯性体位平均眼压及眼压波动均高于对照组。两组内夜间灌注压均较日间低,且POAG患者有更大的MOPP波动。由日间眼压推导夜间峰值眼压具有一定的可行性。
[Abstract]:Objective: to investigate the fluctuation tendency of habitual position pressure (IOP) and intraocular perfusion pressure (IOP) in patients with primary open angle glaucoma (primary open angle glaucoma Poag), and to verify the feasibility of deriving nocturnal peak IOP from daytime mean sitting position and supine IOP. Methods: intraocular pressure (IOP) and blood pressure monitoring were performed in 19 patients with POAG (19 eyes) and 18 normal subjects (18 eyes) at 10: 00 to 14: 00 and 22:00, respectively, in order to verify the feasibility of deducing nocturnal peak intraocular pressure from daytime lying intraocular pressure. In addition, the POAG group was monitored again after lying 5min. 2: 00: 5: 00 and 7:00. The parallel data of OPP were calculated and analyzed. The nocturnal peak IOP was calculated by the known formula and compared with the actual value. Results the mean intraocular pressure and intraocular pressure fluctuation in Poag group were higher than those in normal control group (P0.05). The peak of IOP in Poag group was 5: 00 in the morning and 7: 00 in control group. The mean nocturnal IOP in the two groups was higher than that in the daytime, and the difference was statistically significant (P0.05). The mean intraocular perfusion pressure (MOPP) of the two groups was significantly lower than that of the daytime (P0.05), but there was no significant difference in MOPP between the two groups (P0.05). The MOPP fluctuation of Poag patients was larger than that of the control group (P0.05). The nocturnal IOP peak was not significantly different from the measured values (P0.05). Conclusion: the peak of IOP in POAG group and normal subjects was higher than that in control group from early morning to morning in Poag patients. The nocturnal perfusion pressure in both groups was lower than that in daytime, and MOPP fluctuated more in patients with POAG. It is feasible to deduce nocturnal peak IOP from daytime IOP.
【作者单位】：安徽医科大学附属北京大学深圳医院北京大学深圳医院眼科;
【分类号】：R775.2

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