玻璃酸钠联合重组人表皮生长因子滴眼液对老年白内障术后干眼症泪膜的疗效

发布时间：2018-08-16 14:22

【摘要】：目的探讨玻璃酸钠联合重组人表皮生长因子(rh EGF)滴眼液对老年白内障术后干眼症泪膜的疗效。方法白内障术后干眼症患者85例,依据随机数字表法分为观察组(45例)和对照组(40例)。对照组给予玻璃酸钠治疗,观察组同时给予玻璃酸钠联合rh EGF滴眼液联合治疗。对比两组临床疗效、泪膜破裂时间(BUT)、泪液分泌长度、角膜荧光素染色(FL)评分,并检测两组治疗前后白细胞介素(IL)-6和肿瘤坏死因子(TNF)-α水平。结果观察组治疗总有效率显著高于对照组(P0.05)。治疗后两组BUT均升高,泪液分泌长度、FL评分、IL-6和TNF-α水平均降低,且观察组以上各指标改善更明显(P0.05)。结论玻璃酸钠联合rh EGF滴眼液对老年白内障术后干眼症泪膜能够促进泪膜修复、减轻炎症反应,临床效果更好。
[Abstract]:Objective to investigate the effect of sodium hyaluronate combined with recombinant human epidermal growth factor (rh EGF) eye drops on tear film of dry eyes after cataract surgery in elderly patients. Methods Eighty-five patients with dry eye after cataract operation were randomly divided into observation group (45 cases) and control group (40 cases). The control group was treated with sodium hyaluronate and the observation group with sodium hyaluronate combined with rh EGF eye drops. The clinical efficacy, lacrimal film rupture time, (BUT), lacrimal secretion length, corneal fluorescein staining (FL) score, interleukin (IL) -6 and tumor necrosis factor (TNF)-伪 levels before and after treatment were compared between the two groups. Results the total effective rate in the observation group was significantly higher than that in the control group (P0.05). After treatment, BUT increased, and the level of IL-6 and TNF- 伪 decreased in the tear secretion length and FL score, and the above indexes were improved more obviously in the observation group (P0.05). Conclusion Sodium hyaluronate combined with rh EGF eye drops can promote tear film repair and alleviate inflammatory reaction in elderly patients with dry eye disease after cataract surgery, and the clinical effect is better.
【作者单位】：广州医科大学临床技能实验中心;广州中医药大学金沙洲医院神经外科;广州医科大学附属第一医院骨科;石河子大学医学院第一附属医院眼科;
【分类号】：R779.6

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