非功能损伤手术治疗下咽癌的疗效研究

发布时间：2018-08-23 10:06

【摘要】：目的探讨非功能损伤手术对下咽癌的治疗效果。方法选取100例下咽癌患者为观察对象,根据其手术方式不同分为保留喉功能组35例和未保留喉功能组65例。观察两组患者术后恢复情况、生存率、并发症发生率和生活质量的差异。结果保留喉功能组患者的手术时间较未保留喉功能组长(P㩳0.01),而两组患者术中出血量和住院时间差异无统计学意义(P㧐0.05);保留喉功能组患者吞咽、语言和呼吸恢复率高于未保留喉功能组(P㩳0.05);保留喉功能组咽瘘、皮瓣坏死发生率明显低于未保留喉功能组(P㩳0.05),而两组患者术后感染发生率无统计学意义(P㧐0.05);保留喉功能组患者1年和3年生存率明显高于未保留喉功能组(P㩳0.05);两组患者手术前生活质量得分比较差异无统计学意义;术后两组患者的生活质量均较手术前降低,且未保留喉功能组降低更明显(P㩳0.05)。结论非功能损伤性手术对下咽癌有较好的治疗效果,可明显促进患者术后吞咽、语言和呼吸功能的恢复,提高患者术后生活质量。
[Abstract]:Objective to investigate the effect of nonfunctional injury surgery on hypopharyngeal carcinoma. Methods 100 patients with hypopharyngeal carcinoma were selected and divided into two groups according to their different surgical methods: laryngeal preservation group (n = 35) and unpreserved laryngeal function group (n = 65). The difference of postoperative recovery, survival rate, complication rate and quality of life between the two groups was observed. Results the operative time of the patients with laryngeal preservation function was longer than that of the patients without laryngeal function (P0.01), but there was no significant difference between the two groups in the amount of blood loss and the length of hospitalization (P0. 05), and the patients in the group of reserving laryngeal function had swallowing. The recovery rate of language and respiration was higher than that of the group without laryngeal function (P0. 05). The incidence of flap necrosis was significantly lower than that of unpreserved laryngeal function group (P0. 05), but the incidence of postoperative infection in both groups was not statistically significant (P0. 05), the 1-and 3-year survival rate of laryngectomy group was significantly higher than that of non-preserved laryngeal function group (P0. 05). There was no significant difference in the scores of quality of life before operation. The quality of life in the two groups was lower than that before operation, and that in the group without laryngeal function was significantly lower (P0. 05). Conclusion Non-functional injury surgery has a good therapeutic effect on hypopharyngeal carcinoma. It can obviously promote the recovery of swallowing, speech and respiratory function, and improve the quality of life of the patients after operation.
【作者单位】：辽宁省肿瘤医院头颈外科;
【分类号】：R739.63

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