重度阻塞性睡眠呼吸暂停低通气综合征患者的肺功能分析

发布时间：2018-08-27 07:11

【摘要】：目的·探讨重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的肺功能变化。方法·以打鼾就诊并通过整夜多导睡眠(PSG)监测,达到重度OSAHS的患者入选为研究对象,选取PSG检查正常的自愿者作为对照组。2组均行肺功能检查,选取用力肺活量(FVC)、一秒用力呼出容积(FEV1)、FEV1/FVC、肺总量(TLC)实/预(实测值与预计值比值)、50%肺活量流速(PEF50)实/预、最大呼气中段流速(MMEF)实/预、一氧化碳弥散量(DLCO)实/预、气道总阻力(R5)实/预作为研究指标,对比2组指标差异有无统计学意义。结果·2组肺功能指标FVC、FEV1、FEV1/FVC、TLC实/预、DLCO实/预、R5实/预差异均无统计学意义,MMEF实/预(P=0.036)、PEF50实/预(P=0.043)差异有统计学意义。结论·重度OSAHS患者早期肺功能损害主要表现为小气道病变,应进行小气道功能监测,避免肺功能损害进一步加重。
[Abstract]:Objective to investigate the changes of pulmonary function in patients with severe obstructive sleep apnea hypopnea syndrome (OSAHS). Methods patients with severe OSAHS were enrolled in the study with snoring and polysomnography (PSG) monitoring throughout the night. Volunteers with normal PSG were selected as control group (group .2). Forced vital capacity (FVC),) in one second forced exhalation volume (FEV1) and FEV1 / FVC, total lung volume (TLC) solid / pre (ratio of measured value to predicted value) of 50% vital flow rate (PEF50), maximum mid-expiratory flow rate (MMEF) / pre), carbon monoxide dispersion volume (DLCO) / preconditioning were selected. Total airway resistance (R 5) was used as an index to compare the difference between the two groups. Results there was no significant difference in pulmonary function between the two groups in terms of FVC,FEV1,FEV1/FVC,TLC solid / pretreated DLCO / pretreated R5 / P0. 036, PEF50 / P0. 043. Conclusion the early stage pulmonary function damage in severe OSAHS patients is mainly small airway disease, so small airway function monitoring should be carried out to avoid further exacerbation of lung function damage.
【作者单位】：重庆医科大学附属南川人民医院;
【基金】：重庆市卫生局科研项目(20132241)~~
【分类号】：R766

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