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新疆维汉民族OSAHS患者血清A-FABP相关性研究

发布时间:2018-08-28 15:15
【摘要】:目的:探讨新疆维汉民族阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者与空腹血清脂肪细胞型脂肪酸结合蛋白(A-FABP)的相互关系。方法:采取完全随机方法抽取经多导睡眠监测(PSG)确诊为OSAHS的维族及汉族患者各60例,并选取维族及汉族各52例健康体检者做为对照组,采用酶联免疫法(ELISA)测定两组血清A-FABP水平。结果:OSAHS患者血清A-FABP与其颈围、腰围、腹围、AHI、BMI、最长呼吸暂停时间均呈正相关(P<0.01),与最低血氧饱和度呈负相关(P<0.01),且其BMI、A-FABP均大于正常对照组,在OSAHS患者中维族与汉族比较年龄、BMI、睡眠呼吸暂停低通气指数(AHI)、颈围、腰围、腹围、最低血氧饱合度(LSaO2)、最长呼吸暂停时间(Tmax)、A-FABP,,发现维族患者A-FABP高于汉族(P<0.05),其余均无统计学意义。结论:除去年龄、性别的影响,OSAHS患者血清A-FABP水平、BMI显著高于非OSAHS组。维族OSAHS患者BMI,血清A-FABP水平高于汉族OSAHS患者,OSAHS可能是空腹血清A-FABP升高的原因,维族OSAHS患者空腹血清A-FABP水平高于汉族OSAHS患者,值得进一步讨论。
[Abstract]:Objective: to investigate the relationship between fasting serum adipocyte fatty acid binding protein (A-FABP) and obstructive sleep apnea hypopnea syndrome (OSAHS) in Xinjiang. Methods: totally random methods were used to select 60 Uygur and Han patients with OSAHS diagnosed by polysomnography (PSG), and 52 healthy controls (Uygur and Han) as control group. The serum A-FABP levels were measured by Elisa (ELISA) in both groups. Results Serum A-FABP was positively correlated with neck circumference, waist circumference, abdominal circumference, longest apnea time (P < 0. 01), negatively correlated with minimum oxygen saturation (P < 0. 01), and its BMI,A-FABP was higher than that of control group. In OSAHS patients, the age, (AHI), neck circumference, waist circumference, abdominal circumference, minimum degree of oxygen saturation (LSaO2) and longest apnea time (Tmax) were higher in Uygur than in Han nationality (P < 0. 05). The A-FABP in Uygur patients was higher than that in Han nationality (P < 0. 05). Conclusion: the influence of age and sex on serum A-FABP level in OSAHS patients was significantly higher than that in non OSAHS patients. The serum A-FABP level of BMI, in Uygur OSAHS patients is higher than that of OSAHS patients in Han nationality. The fasting serum A-FABP level in Uygur OSAHS patients is higher than that in OSAHS patients of Han nationality, which is worthy of further discussion.
【学位授予单位】:新疆医科大学
【学位级别】:硕士
【学位授予年份】:2012
【分类号】:R766

【参考文献】

相关期刊论文 前10条

1 李永霞;董昭兴;钟红;海冰;张涛;;不同肥胖程度和阻塞性睡眠呼吸暂停综合征的研究[J];中国医师杂志;2006年06期

2 黄陆颖,余贤恩;肥胖与阻塞性睡眠呼吸暂停[J];国外医学.呼吸系统分册;2001年01期

3 刘茜,吴亚梅,徐玲;肥胖、瘦素和呼吸功能[J];国外医学.呼吸系统分册;2005年10期

4 狄枫;王任烨;王良兴;;OSAHS与代谢综合征的关系探讨[J];国外医学(内科学分册);2006年12期

5 胡宝明,叶京英;女性激素与阻塞性睡眠呼吸暂停低通气综合征[J];国外医学.耳鼻咽喉科学分册;2004年05期

6 郑昕;李建军;郭远林;慕朝伟;张朝阳;高展;戴军;;45岁以下女性冠心病患者危险因素及冠状动脉造影特点分析[J];中国动脉硬化杂志;2007年10期

7 金静;彭道泉;赵水平;宁小晖;李松林;王淑慧;;血清脂肪细胞型脂肪酸结合蛋白与冠心病及其危险因素的相关性[J];中国动脉硬化杂志;2009年10期

8 郑明秀;王玫;;阻塞性睡眠呼吸暂停低通气综合征与肥胖及血清抵抗素水平关系的研究[J];临床耳鼻咽喉头颈外科杂志;2008年02期

9 叶民,谢于鹏,叶彩儿,徐晓梅,张冬青,徐红蕾;体重指数与阻塞性睡眠呼吸暂停低通气综合征的关系[J];浙江临床医学;2005年10期

10 王静;林勇;徐春华;;阻塞性睡眠呼吸暂停低通气综合征患者血浆ghrelin水平的变化及其意义[J];东南大学学报(医学版);2007年04期



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