初诊鼻咽癌患者血清C反应蛋白检测临床意义分析

发布时间：2018-08-30 15:45

【摘要】：目的 C反应蛋白(C reactive protein,CRP)可能是肿瘤和炎症之间的桥梁,有研究证实CRP水平和鼻咽癌分期相关。本研究旨在探讨放疗前血清中CRP水平与临床特征之间的关系,并判断其在预测鼻咽癌患者疗效和预后的价值。方法随访2006-12-27-2011-07-27中山大学肿瘤防治中心治疗的初诊鼻咽癌患者227例。227例患者全部入组了国家863计划项目资助的课题"以生物学行为和分子特征为基础的鼻咽癌个性化治疗新方案的研究"。临床分期依据2002AJCC/UICC分期标准。所有患者接受直线加速器6~8 MV高能X射线放疗,216例患者均接受同期化疗。采用χ2检验,分析CRP表达情况与患者一般临床特征的相关性;采用Kaplan-Meier法,分析治疗前CRP对鼻咽癌患者近期疗效以及总生存率、局部无复发率和无远处转移率等远期疗效的影响。结果在227例鼻咽癌患者血清中,CRP在不同的N分期(P=0.017)、M分期(P=0.010)及病理分型(P0.001)之间差异有统计学意义。227例鼻咽癌患者治疗前,CRP正常195例,异常32例。血清CRP正常患者的总生存率(88.2%)高于异常患者(71.8%),P=0.022;无远处转移率(86.7%)也高于异常患者(68.7%),P=0.027。结论鼻咽癌患者治疗前CRP表达升高,会显著降低鼻咽癌患者的总生存率及无远处转移生存率,是影响预后的不利因素。
[Abstract]:Objective C-reactive protein (CRP) may be a bridge between tumor and inflammation. Studies have confirmed that CRP levels are correlated with stage of nasopharyngeal carcinoma. 227 newly diagnosed patients with nasopharyngeal carcinoma were enrolled in the National 863 Program sponsored by the National 863 Program. The clinical staging was based on the 2002AJCC/UICC staging criteria. The correlation between CRP expression and general clinical features was analyzed by_2 test, and the effect of CRP on short-term efficacy, overall survival rate, local recurrence rate and distant metastasis rate was analyzed by Kaplan-Meier method. Results In 227 patients with nasopharyngeal carcinoma, CRP was significantly different in N stage (P = 0.017), M stage (P = 0.010) and pathological type (P 0.001). Before treatment, 195 patients with normal CRP and 32 patients with abnormal CRP were found. The overall survival rate of patients with normal serum CRP (88.2%) was higher than that of patients with abnormal CRP (71.8%) and no distant metastasis (86.7%). Conclusion The increase of CRP expression in NPC patients before treatment can significantly reduce the overall survival rate and the survival rate without distant metastasis of NPC patients, which is a disadvantageous factor affecting the prognosis.
【作者单位】：华南肿瘤学国家重点实验室;中山大学肿瘤防治中心放疗科;解放军第四二一医院肿瘤科;宜昌市中心人民医院肿瘤科;安徽省肿瘤医院放疗科;
【基金】：国家863计划项目(2006AA02Z4B4) 国家自然科学基金(30070237)
【分类号】：R739.63

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