羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效

发布时间：2018-09-03 07:13

【摘要】：目的观察羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效及安全性。方法将58例老年2型糖尿病早期视网膜病变患者随机分为对照组29例和试验组29例。对照组予以羟苯磺酸钙每次0.5g,tid,口服;试验组在对照组治疗的基础上,予以丹参注射液20 mL,qd,静脉滴注,治疗2周停药1周。2组患者均治疗3个月。比较2组患者的临床疗效、血管内皮细胞生长因子(VEGF)、胰岛素样生长因子1(IGF-1)、超敏C-反应蛋白(hs-CRP)水平,以及药物不良反应的发生情况。结果治疗后,试验组和对照组的总有效率分别为93.10%(27/29例)和72.41%(21/29例),差异有统计学意义(P0.05)。治疗后,试验组和对照组的血清VEGF分别为(82.32±9.73)和(105.24±10.05)pg·mL~(-1),IGF-1分别为(89.66±8.79)和(124.24±9.86)ng·mL~(-1),hs-CRP分别为(3.98±0.52)和(6.76±0.83)mg·L~(-1),差异均有统计学意义(均P0.05)。试验组的药物不良反应主要有面部潮红和恶心呕吐,对照组的药物不良反应主要有恶心呕吐和食欲缺乏。试验组和对照组的药物不良反应发生率分别为10.34%和6.90%,差异无统计学意义(P0.05)。结论羟苯磺酸钙胶囊联合丹参注射液治疗老年2型糖尿病早期视网膜病变的临床疗效显著,其能够明显降低患者的血清VEGF、IGF-1及hs-CRP水平,且不增加药物不良反应的发生率。
[Abstract]:Objective to observe the clinical efficacy and safety of calcium dobesilate capsule combined with salvia miltiorrhiza injection in the treatment of early diabetic retinopathy in the elderly. Methods 58 elderly patients with early diabetic retinopathy were randomly divided into control group (n = 29) and experimental group (n = 29). The control group was given calcium dobesilate 0.5 g tid each time, and the experimental group was given salvia miltiorrhiza injection 20 mL,qd, intravenous drip on the basis of the control group. The clinical efficacy, the levels of vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), hypersensitive C-reactive protein (hs-CRP) and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 93.10% (27 / 29 cases) and 72.41% (21 / 29 cases), respectively. The difference was statistically significant (P0.05). After treatment, the serum VEGF levels in the experimental group and the control group were (82.32 卤9.73) and (105.24 卤10.05) pg mL~ (-1), respectively (89.66 卤8.79) and (124.24 卤9.86) ng mL~ (-1), respectively (3.98 卤0.52) and (6.76 卤0.83) mg L ~ (-1), respectively (P0.05). The main adverse drug reactions in the trial group were facial flushing and nausea and vomiting, while in the control group, nausea and vomiting and appetite deficiency were the main adverse drug reactions. The incidence of adverse drug reactions in the test group and the control group was 10.34% and 6.90%, respectively. The difference was not statistically significant (P0.05). Conclusion calcium dobesilate capsule combined with Salvia miltiorrhiza injection is effective in the treatment of early retinopathy in elderly patients with type 2 diabetes mellitus. It can significantly reduce the levels of serum VEGF,IGF-1 and hs-CRP and do not increase the incidence of adverse drug reactions.
【作者单位】：齐齐哈尔医学院第一附属医院眼科;靖江市人民医院眼科;
【基金】：国家自然科学基金资助项目(81170856)
【分类号】：R587.2;R774.1

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