近视眼脉络膜厚度与近视程度的相关性分析

发布时间：2018-09-03 15:44

【摘要】：目的评价中国近视人群黄斑区脉络膜厚度与近视程度的相关性。设计回顾性病例系列。研究对象北京同仁眼科中心拟行近视矫正手术者248例470眼。方法用RTVue OCT进行脉络膜视网膜扫描,手工测量中心凹处和距离中心凹500、1000、2000μm处上、下、鼻、颞侧13个点上的脉络膜厚度。视网膜厚度计算是设备测量软件自动生成的以距离黄斑中心凹1、3、6 mm的圆内选取8个测量值的平均值。近视程度分为轻(-0.50~-3.00 D)、中(-3.25~-6.00 D)、高(-6.25~-9.00 D)、超高(-9.00 D)度近视四个组。主要指标脉络膜厚度、视网膜厚度、眼轴长度。结果在中心凹和其他测量点上脉络膜厚度在轻度、中度近视组间无显著差别,在轻度和高度、轻度和超高度、中度和高度、中度和超高度、高度和超高度近视眼组间均有显著性差别(P均0.01)。中心凹处视网膜厚度在各组之间无显著差别(P均0.05)。在超高度近视组和总样本内眼轴长度和等效球镜绝对值与黄斑区脉络膜厚度呈负相关。总样本内年龄和最佳矫正视力与黄斑区脉络膜厚度相关。黄斑区视网膜厚度与年龄、眼轴长度、等效球镜绝对值无显著相关,与黄斑区脉络膜厚度呈正相关。在轻度、中度近视组中心凹下脉络膜厚度比黄斑区脉络膜厚度更厚,而在高度和超高度近视组中心凹下脉络膜厚度比黄斑区脉络膜厚度更薄;这种差别在轻度和超高度近视组间有显著统计学意义(P0.001)。在正常与异常最佳矫正视力的两组间黄斑区脉络膜厚度与中心凹下脉络膜厚度显著不同(P0.05)。年龄(P=0.019)和黄斑区脉络膜厚度(P0.01)与总样本的最佳矫正视力独立相关(P0.05)。结论黄斑区的脉络膜厚度越薄,高度近视的可能越大,越容易出现影响最佳矫正视力的近视黄斑病变。
[Abstract]:Objective to evaluate the correlation between choroidal thickness in macular area and myopia in Chinese myopic population. Design retrospective case series. Participants 248 patients (470 eyes) with myopia correction were studied in Beijing Tongren Eye Center. Methods RTVue OCT was used to scan the choroid and retina. The thickness of choroid was measured manually at the fovea of the center and at the top, the lower nose, the nose, and the temporal side of the central fovea at 1000 ~ 2000 渭 m from the fovea. The calculation of retinal thickness is the average value of 8 measured values in a circle of 1 ~ 3 ~ 6 mm from the fovea of macula, which is generated automatically by the equipment measurement software. Myopia degree was divided into four groups: light (-0.50) -3.00 D), (-3.25 ~ 6.00 D),) high (-6.25 D), -9.00 D),) high (-9.00 D) myopia. Main outcome measures choroidal thickness retinal thickness and axial length. Results there was no significant difference in choroidal thickness between mild and moderate myopia groups at the fovea and other measurement points. There was significant difference between the high myopia group and the ultra high myopia group (P 0.01). There was no significant difference in retinal thickness between each group (P 0.05). In ultra-high myopia group and total sample, the axial length and the absolute value of equivalent spherical lens were negatively correlated with the choroidal thickness of macular area. Age in the total sample and best corrected visual acuity were correlated with choroidal thickness in the macular area. There was no significant correlation between retinal thickness of macular area and age, axial length, absolute value of equivalent spherical lens, but positive correlation with choroidal thickness of macular area. In mild, moderate myopia group, the thickness of central foveal choroid was thicker than that of macular area, while in high and ultra-high myopia group, the thickness of central foveal choroid was thinner than that of macular region. This difference was statistically significant between mild and ultra-high myopia (P0.001). The choroidal thickness in macular area was significantly different from that in subcentral fovea in normal and abnormal BCVA groups (P0.05). Age (P0. 019) and macular choroidal thickness (P0. 01) were independently correlated with BCVA (P0.05). Conclusion the thinner the choroidal thickness in the macular area, the greater the likelihood of high myopia and the more prone to macular lesions affecting the best corrected visual acuity.
【作者单位】：首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所;眼科学与视觉科学北京市重点实验室;
【分类号】：R778.11

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