上海金山化工地区鼻咽癌流行病学调查及化工相关病因分析
发布时间：2018-09-03 16:12
【摘要】：目的以上海金山化工地区为调查对象,分析化工地区鼻咽癌的流行特点。 方法获取金山地区与周围奉贤、松江等地区的鼻咽癌发病率、死亡率资料,进行比较分析；收集2005年1月1日至2011年8月31日在复旦大学附属金山医院就诊的全部金山籍初诊、初治鼻咽癌患者共119例,根据就诊时登记的信息,对性别、年龄、病理类型、首诊症状及临床分期等临床资料进行统计分析。 结果金山地区2002-2007年鼻咽癌的平均发病率为2.505/105,与周围的奉贤、松江等地区相比,发病率和死亡率无统计学差异(P0.05),与广东、广西等高发病地区相比,金山地区发病率较低,且无明显的升高或降低趋势；男女发病率之比为2.45：1,发病年龄集中在30-70岁,病理类型中以未分化癌和低分化癌为主,分别占45.38%和40.34%,临床分期以Ⅱ期、Ⅲ期为主。 结论金山化工区属鼻咽癌的非高发区,肿瘤恶性程度较高,多数患者就诊时已处于临床中晚期。 目的以上海金山化工地区为调查对象,探讨化工相关因素对鼻咽癌发病的影响。 方法采用病例-对照研究的方法,对108名于2005年1月1日至2011年8月31日在复旦大学附属金山医院就诊的初发鼻咽癌的患者进行病因调查,然后对各因素进行单因素的logistic回归分析,再将筛查出来的影响因素进行多因素的logistic回归分析。调查内容主要为与化工相关的因素。 结果对化工相关因素进行单因素及多因素的logistic回归分析,结果表明在化工地区接触农药(OR=3.68)和职业接触化学物质(OR=3.89)是鼻咽癌发病主要的化学危险因素,而接触过程中采取有效的防护措施可以降低危险度。 结论职业与化工企业相关可以增加鼻咽癌发病的风险,但接触过程中有效的防护措施可以降低这一危险度。
[Abstract]:Objective to analyze the epidemic characteristics of nasopharyngeal carcinoma (NPC) in Jinshan chemical region of Shanghai. Methods the data of incidence and mortality of nasopharyngeal carcinoma in Jinshan area, Fengxian and Songjiang areas were collected and analyzed, and all the patients who were admitted to Jinshan Hospital of Fudan University from January 1, 2005 to August 31, 2011 were collected. A total of 119 patients with nasopharyngeal carcinoma were treated. According to the information registered at the time of visit, the clinical data such as sex, age, pathological type, first diagnosis symptom and clinical stage were analyzed statistically. Results the average incidence of nasopharyngeal carcinoma in Jinshan from 2002 to 2007 was 2.505 / 105. There was no significant difference in morbidity and mortality between Jinshan and Fengxian and Songjiang (P0.05). Compared with high incidence areas such as Guangdong and Guangxi, the incidence of nasopharyngeal carcinoma in Jinshan was lower than that in Jinshan. The incidence ratio of male and female was 2.45: 1. The age of onset was 30-70 years old. The pathological types were mainly undifferentiated carcinoma and poorly differentiated carcinoma, accounting for 45.38% and 40.34%, respectively. The clinical stages were mainly stage 鈪，
本文编号：2220493
[Abstract]:Objective to analyze the epidemic characteristics of nasopharyngeal carcinoma (NPC) in Jinshan chemical region of Shanghai. Methods the data of incidence and mortality of nasopharyngeal carcinoma in Jinshan area, Fengxian and Songjiang areas were collected and analyzed, and all the patients who were admitted to Jinshan Hospital of Fudan University from January 1, 2005 to August 31, 2011 were collected. A total of 119 patients with nasopharyngeal carcinoma were treated. According to the information registered at the time of visit, the clinical data such as sex, age, pathological type, first diagnosis symptom and clinical stage were analyzed statistically. Results the average incidence of nasopharyngeal carcinoma in Jinshan from 2002 to 2007 was 2.505 / 105. There was no significant difference in morbidity and mortality between Jinshan and Fengxian and Songjiang (P0.05). Compared with high incidence areas such as Guangdong and Guangxi, the incidence of nasopharyngeal carcinoma in Jinshan was lower than that in Jinshan. The incidence ratio of male and female was 2.45: 1. The age of onset was 30-70 years old. The pathological types were mainly undifferentiated carcinoma and poorly differentiated carcinoma, accounting for 45.38% and 40.34%, respectively. The clinical stages were mainly stage 鈪，
本文编号：2220493
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