自拟减毒汤联合康复新对鼻咽癌患者放疗不良反应的减毒效果观察

发布时间：2018-09-11 21:26

【摘要】：目的:探讨自拟减毒汤加减联合康复新对鼻咽癌患者放疗不良反应的减毒效果观察。方法:选取2013年7月—2015年7月接受放射治疗的鼻咽癌患者96例(完成86例,脱落10例)作为研究对象,采用随机数字表法分为观察组(48例,完成44例,脱落4例)和对照组(48例,完成42例,脱落6例),对照组给予康复新治疗,观察组在对照组基础上给予自拟减毒汤加减治疗,以放疗结束作为干预终点,记录两组放射不良反应发生率、发生时间、持续时间,采用卡氏评分(KPS)评估功能状态,计算体质量指数(BMI)。结果:观察组口腔黏膜损伤、放射性食管炎、放射性皮肤损伤、口干的Ⅲ~Ⅳ级发生率分别为20.45%、9.09%、9.09%、6.82%,明显低于对照组的42.86%、28.57%、35.71%、30.95%;观察组口腔黏膜损伤、放射性食管炎、放射性皮肤损伤、口干的出现时间长于对照组,口腔黏膜损伤、放射性食管炎、放射性皮肤损伤持续时间短于对照组(P0.05);观察组治疗后KPS评分、BMI高于对照组(P0.05)。结论:自拟减毒汤加减联合康复新可减轻鼻咽癌患者放疗不良反应严重程度,延长不良反应出现时间,减少对生活质量、体质量的影响。
[Abstract]:Objective: to observe the antitoxic effect of self-made detoxification decoction combined with Kangfuxin on adverse reaction of radiotherapy in patients with nasopharyngeal carcinoma (NPC). Methods: 96 patients with nasopharyngeal carcinoma received radiotherapy from July 2013 to July 2015 were selected as the study objects. The patients were randomly divided into observation group (48 cases) and complete treatment group (44 cases). The control group (48 cases, 42 cases, 6 cases), the control group was treated with new rehabilitation therapy, the observation group was treated with self-made attenuated decoction on the basis of the control group, and the end of radiotherapy was taken as the end point of the intervention. The incidence, time and duration of adverse effects of radiation were recorded. The functional status was evaluated by (KPS) and the body mass index (BMI).) was calculated. Results: the incidence of oral mucosal injury, radiation esophagitis, radiation skin injury and dry mouth in the observation group were 20.459.099.099.09 and 6.82 respectively, which were significantly lower than that in the control group (42.866.57 and 28.577.75), the oral mucosal injury, radiation esophagitis and radiation skin injury were observed in the observation group. Dry mouth appeared longer than the control group, oral mucosal injury, radiation esophagitis, radiation skin injury duration was shorter than the control group (P0.05); the observation group after treatment KPS score was higher than the control group (P0.05). Conclusion: Self-made Jiandu decoction combined with rehabilitation can reduce the severity of radiotherapy adverse reactions, prolong the occurrence time of adverse reactions and reduce the impact on quality of life and body mass in nasopharyngeal carcinoma patients.
【作者单位】：昆明医科大学第三附属医院云南省肿瘤医院放疗科;
【分类号】：R739.63

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