鼻咽低级别甲状腺样乳头状癌1例并文献复习

发布时间：2018-09-12 09:31

【摘要】：目的探讨鼻咽低级别甲状腺样乳头状癌的临床病理学特征、免疫表型、鉴别诊断及预后。方法分析1例鼻咽低级别甲状腺样乳头状癌的临床病理学特征,并复习相关文献。结果患者女性,16岁,流涕和鼻塞1个月,无甲状腺病变及其他异常。鼻内镜检查发现后鼻中隔带蒂息肉样肿物,表面光滑,行内镜下肿物切除。镜下肿瘤组织呈明显的乳头状结构,乳头排列较紧密,大小不一,个别乳头中央间质水肿,可见纤维血管轴心,乳头表面衬覆单层或假复层柱状细胞,细胞核呈圆形或者卵圆形,核仁不明显,胞质嗜酸或局灶透明,核分裂象罕见,可见钙化及砂砾体。免疫表型:肿瘤细胞表达CKpan、TTF-1、CK7、EMA、vimentin,Ki-67增殖指数小于3%。结论鼻咽低级别甲状腺样乳头状癌属于非常罕见的鼻咽低级别腺癌,结合临床病理特征及免疫表型有助于诊断;治疗主要采取手术完整切除,预后较好。
[Abstract]:Objective to investigate the clinicopathological features, immunophenotype, differential diagnosis and prognosis of low grade thyroid papillary carcinoma of nasopharynx. Methods the clinicopathological features of a case of nasopharyngeal low grade thyroid papillary carcinoma were analyzed and the related literatures were reviewed. Results the female patients were 16 years old, snot and nasal obstruction for 1 month, no thyroid lesions or other abnormalities. Nasal endoscopy revealed the posterior nasal septum pedicled polyp-like tumor, smooth surface, endoscopic tumor resection. Under the microscope, the tumor tissue showed obvious papillary structure, the papilla arranged tightly, the size was different, the central interstitial edema of some papilla, the axis of fibrovascular, the papilla surface was lined with monolayer or pseudostratified columnar cells. The nucleus is round or oval, the nucleolus is not obvious, the cytoplasm is eosinophilic or focal transparent, the mitosis is rare, calcification and sandy gravel can be seen. Immunophenotype: CKpan,TTF-1,CK7,EMA,vimentin,Ki-67 proliferation index of tumor cells was less than 3%. Conclusion low grade thyroid papillary carcinoma of nasopharynx is a very rare low grade carcinoma of nasopharynx, which can be diagnosed by combining clinicopathological features and immunophenotype.
【作者单位】：首都医科大学附属复兴医院病理科;浙江省绍兴市人民医院病理科;湖北省武汉市黄陂区中医医院病理科;
【基金】：浙江省医学扶植重点建设学科计划(GJSX-010-004)
【分类号】：R739.63

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