圆锥角膜的光密度分析

发布时间：2018-09-13 16:01

【摘要】：目的使用Pentacam对圆锥角膜和健康角膜的光密度进行测量,比较健康角膜与不同等级圆锥角膜的透明度。方法使用Pentacam眼前节分析系统测量对照组(30例30眼正常角膜)以及圆锥角膜组(36例36眼圆锥角膜)的光密度,以角膜顶点为中心,分别测量0~2 mm、2~6 mm、6~10 mm、10~12 mm直径范围的前层(120μm)、后层(60μm)以及中间层的角膜光密度。使用Amsler-Krumeich分级方法对圆锥角膜进行分级,对比不同等级光密度差异。分析圆锥角膜光密度与厚度、陡峭K值的相关性。结果总直径的全层角膜光密度圆锥角膜组(17.96±3.23)和对照组(17.39±1.95)之间差异无统计学意义(P=0.124);但是在0~2 mm直径范围内的前层、中层、全层,2~6 mm直径范围内的前层以及总直径的前层中,圆锥角膜组的光密度均显著高于对照组(均为P0.05)。按照圆锥角膜等级分组,对照组角膜光密度与轻度圆锥角膜组各层比较,差异均无统计学意义(均为P0.05),但对照组角膜光密度与中度圆锥角膜组0~2 mm直径范围内的前层比较差异有统计学意义(P0.05)。重度圆锥角膜在0~2 mm直径范围内各层光密度较对照组、轻度圆锥角膜组、中度圆锥角膜组均显著增高(均为P0.05),在2~6 mm直径范围和总直径的前层、中层和全层与其余三组相比均显著增加(均为P0.05)。圆锥角膜组的陡峭K值与0~2 mm直径范围的总角膜光密度显著相关(P0.05)。圆锥角膜组的角膜顶点以及角膜最薄点的厚度与光密度也存在明显的相关性(均为P0.05)。结论相比正常角膜,轻度圆锥角膜光密度不发生改变,中度圆锥角膜光密度增高主要发生于角膜前层0~2 mm直径范围内,重度圆锥角膜光密度增高主要发生于角膜前层0~6 mm直径范围内和角膜中层2 mm直径范围内,而且圆锥角膜光密度随疾病发展而增高。角膜光密度是圆锥角膜的一个重要参考指标,可以用来检测圆锥角膜发病进程以及治疗效果。
[Abstract]:Objective to measure the optical density of keratoconus and healthy cornea by Pentacam, and to compare the transparency between healthy cornea and different grades of keratoconus. Methods the optical density of the control group (30 cases, 30 eyes) and the conus group (36 cases, 36 eyes) was measured by Pentacam anterior segment analysis system. The optical density of the anterior layer (120 渭 m), posterior layer) and the middle layer (60 渭 m) in the 0 ~ 2 mm,2~6 mm,6~10 mm,10~12 mm diameter range were measured respectively. The keratoconus was graded by Amsler-Krumeich method and the difference of optical density was compared. The correlation between optical density and thickness and steep K value of keratoconus was analyzed. Results there was no significant difference in total diameter between the keratoconus group (17.96 卤3.23) and the control group (17.39 卤1.95), but there was no significant difference in the anterior layer, the middle layer, the whole layer and the total diameter in the anterior layer, the middle layer, the whole layer and the total diameter of the keratoconus group (P < 0.05). The optical density of keratoconus group was significantly higher than that of control group (P0.05). According to the grade of keratoconus, the light density of the control group was compared with that of the mild keratoconus group. There was no significant difference between the two groups (P0.05), but the corneal optical density in the control group was significantly higher than that in the moderate keratoconus group within the diameter of 0 ~ 2 mm (P0.05). The optical density of severe keratoconus in 0 ~ 2 mm diameter range was significantly higher than that in control group. In mild keratoconus group, moderate keratoconus group was significantly higher than that in control group (P0.05), and the anterior layer of 2 ~ 6 mm diameter and total diameter of severe keratoconus cornea were significantly higher than that of control group. The middle layer and the whole layer were significantly increased compared with the other three groups (P0.05). The steep K value of keratoconus group was significantly correlated with the total corneal optical density in the 0 ~ 2 mm diameter range (P0.05). There was also a significant correlation between the corneal vertex and the thickness of the thinnest point and the optical density in the keratoconus group (P0.05). Conclusion compared with the normal cornea, the light density of the mild keratoconus does not change, and the increase of the light density of the moderate keratoconus occurs mainly in the range of 0 ~ 2 mm diameter of the anterior layer of the cornea. The increase of optical density of severe keratoconus occurred mainly in the range of 0 ~ 6 mm diameter of the anterior layer of cornea and 2 mm diameter of the middle layer of cornea, and the optical density of keratoconus increased with the development of the disease. Corneal optical density is an important index of keratoconus, which can be used to detect the pathogenesis and therapeutic effect of keratoconus.
【作者单位】：天津医科大学眼科医院;
【分类号】：R772.2

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