鼻咽癌患者外周血凝血功能异常的临床分析
发布时间：2018-09-18 21:15
【摘要】：目的:通过观察鼻咽癌患者在治疗前凝血功能相关指标(PLT、APTT、PT、TT、FIB)在不同性别、年龄、分期、分化程度及转移情况下的变化,探讨其临床意义,为早期预防血栓栓塞形成和早期使用预防性抗凝药物治疗提供新的思路和理论依据。方法:选取2016年01月至2017年01月期间就诊于贵州省肿瘤医院头颈肿瘤科或耳鼻喉科,经病理活检确诊为鼻咽癌且未经过放疗、化疗等治疗的患者共计132例(男99例,女33例),并选取同期于贵州省肿瘤医院健康体检中心体检的健康体检者68例作为对照组,记录鼻咽癌组和对照组外周血PLT、APTT、PT、TT、FIB,运用SPSS22.0统计软件进行相关分析。结果:1.鼻咽癌组外周血中PLT、APTT、FIB水平明显高于健康对照组(P0.05),PT、TT两组间差异无统计学意义(P0.05);2.鼻咽癌APTT、PT男性组较女性组延长(P0.05);PLT、TT、FIB两组间差异无统计学意义(P0.05);3.鼻咽癌小于等于50岁组PLT、APTT、PT水平明显高于大于50岁组(P0.05),TT水平低于大于50岁组(P0.05);FIB两组间差异无统计学意义(P0.05);4.鼻咽癌组PLT、APTT、FIB水平与T分期、N分期、临床分期有关,分期越晚,水平升高越明显(P0.05);PT、TT与T分期、N分期及临床分期之间无明显差异(P0.05);5.鼻咽癌Ⅳ期非远处转移组PLT、FIB水平明显低于远处转移组(P0.05);而APTT、PT、TT两组间无明显差异(P0.05)。6.鼻咽癌PLT、APTT、PT、TT及FIB水平在非角化分化型与非角化未分化型之间均无明显差异(P0.05);7.鼻咽癌组FIB与T分期、N分期、临床分期及远处转移呈正相关,PLT与远处转移呈正相关,具有统计学意义(P0.05);PLT与T分期、N分期、临床分期无相关性(P0.05);APTT、PT、TT与T分期、N分期、临床分期及远处转移均无相关性(P0.05)。结论:1.鼻咽癌患者外周血PLT、FIB水平明显高于健康对照组,提示鼻咽癌患者体内存在不同程度的高凝状态;2.鼻咽癌患者外周血中FIB水平与T分期、N分期、临床分期及远处转移呈正相关,PLT与远处转移情况呈正相关,发生远处转移者,高凝状态更加显著,提示鼻咽癌晚期发生血检的风险增加。
[Abstract]:Objective: to observe the changes of coagulation function related index (PLT,APTT,PT,TT,FIB) in patients with nasopharyngeal carcinoma (NPC) before treatment under different sex, age, stage, differentiation and metastasis, and to explore its clinical significance. To provide new ideas and theoretical basis for early prevention of thromboembolism and early use of prophylactic anticoagulant therapy. Methods: from January 2016 to January 2017, 132 patients (99 males) with nasopharyngeal carcinoma (NPC) confirmed by pathological biopsy without radiotherapy and chemotherapy were selected from head and neck oncology department or otolaryngology department of Guizhou Provincial Oncology Hospital from January 2016 to January 2017. In this study, 68 healthy persons from the center of health examination of Guizhou Provincial Cancer Hospital were selected as the control group. The peripheral blood PLT,APTT,PT,TT,FIB, of nasopharyngeal carcinoma group and control group were recorded and analyzed by SPSS22.0 statistical software. The result is 1: 1. The level of PLT,APTT,FIB in peripheral blood of nasopharyngeal carcinoma group was significantly higher than that of healthy control group (P0.05). There was no significant difference between the two groups (P0.05). The APTT,PT of nasopharyngeal carcinoma in male group was longer than that in female group (P0.05). There was no significant difference between the two groups (P0.05). The PLT,APTT,PT level of NPC < 50 years old group was significantly higher than that of more than 50 years old group (P0.05). There was no significant difference between the two groups (P0.05). The level of PLT,APTT,FIB in nasopharyngeal carcinoma group was related to T staging and N stage. The later the stage was, the higher the level was (P0.05). There was no significant difference between PTT TT and T staging and N stage and clinical stage (P0.05). The PLT,FIB level of NPC stage 鈪，
本文编号：2249117
[Abstract]:Objective: to observe the changes of coagulation function related index (PLT,APTT,PT,TT,FIB) in patients with nasopharyngeal carcinoma (NPC) before treatment under different sex, age, stage, differentiation and metastasis, and to explore its clinical significance. To provide new ideas and theoretical basis for early prevention of thromboembolism and early use of prophylactic anticoagulant therapy. Methods: from January 2016 to January 2017, 132 patients (99 males) with nasopharyngeal carcinoma (NPC) confirmed by pathological biopsy without radiotherapy and chemotherapy were selected from head and neck oncology department or otolaryngology department of Guizhou Provincial Oncology Hospital from January 2016 to January 2017. In this study, 68 healthy persons from the center of health examination of Guizhou Provincial Cancer Hospital were selected as the control group. The peripheral blood PLT,APTT,PT,TT,FIB, of nasopharyngeal carcinoma group and control group were recorded and analyzed by SPSS22.0 statistical software. The result is 1: 1. The level of PLT,APTT,FIB in peripheral blood of nasopharyngeal carcinoma group was significantly higher than that of healthy control group (P0.05). There was no significant difference between the two groups (P0.05). The APTT,PT of nasopharyngeal carcinoma in male group was longer than that in female group (P0.05). There was no significant difference between the two groups (P0.05). The PLT,APTT,PT level of NPC < 50 years old group was significantly higher than that of more than 50 years old group (P0.05). There was no significant difference between the two groups (P0.05). The level of PLT,APTT,FIB in nasopharyngeal carcinoma group was related to T staging and N stage. The later the stage was, the higher the level was (P0.05). There was no significant difference between PTT TT and T staging and N stage and clinical stage (P0.05). The PLT,FIB level of NPC stage 鈪，
本文编号：2249117
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