初治鼻咽癌调强放射治疗与常规放射治疗近期疗效与副反应的比较
发布时间：2018-10-05 21:57
【摘要】：目的比较鼻咽癌患者调强放射治疗与常规二维放射治疗的疗效和急慢性反应。 方法系统分析2008年5月至2010年12月在福建医科大学附属第一医院放射治疗科同期常规放射治疗及调强放射治疗(IMRT)的初治鼻咽癌患者203例，分为IMRT组（103例）和常规放射治疗组（100例）。常规放射治疗鼻咽部剂量66～74Gy，肿大淋巴结64—68Gy，颈部预防剂量50-52Gy；调强放射治疗设鼻咽大体肿瘤为GTVnx、颈部阳性淋巴结GTVnd，高危临床靶体积CTV1和低危临床靶体积CTV2：。PTVnx：70.08土1.81Gy，PTVnd：67.38土2.58Gy，PTVl：61.46土2.13Gy，，PTV2：54.12土2.04Gy，分31～33次照射。比较IMRT和常规放射治疗患者的急性不良反应如口干、吞咽疼痛、吞咽困难、皮肤和黏膜反应等；晚期损伤中张口困难、肌肉/软组织损伤等方面。 结果与常规组相比，IMRT组的急性不良反应有不同程度的减轻，口干、吞咽疼痛、吞咽困难、皮肤反应和黏膜反应等的发生率较低(P＜0.05)；晚期损伤中张口困难、肌肉/软组织损伤无明显差别。 结论相对于常规放射治疗，IMRT技术能够减轻急性不良反应，改善患者的生存质量。
[Abstract]:Objective to compare the efficacy and acute and chronic response of intensity modulated radiotherapy and conventional two-dimensional radiotherapy in patients with nasopharyngeal carcinoma. Methods from May 2008 to December 2010, 203 patients with nasopharyngeal carcinoma (NPC) who were treated with conventional radiotherapy and intensity modulated radiotherapy (IMRT) in the Department of radiotherapy, first affiliated Hospital of Fujian Medical University were analyzed systematically. The patients were divided into IMRT group (103 cases) and conventional radiotherapy group (100 cases). The dose of nasopharynx was 660.74 Gy, the enlarged lymph node 64-68 Gy, and the cervical preventive dose 50-52 Gy. Intensity modulated radiotherapy (IMRT) for nasopharyngeal gross neoplasms: GTVnx, neck positive lymph node GTVnd, high risk target volume CTV1 and low risk clinical target volume CTV2:.PTVnx:70.08 1. 81Gy: 67.38 卤2.58Gy PTVl: 61.46 卤2.13Gy PTV2: 54.12 卤2.04Gy, 3133 exposures. The acute adverse reactions such as dry mouth, dysphagia, skin and mucosal reaction in patients with IMRT and conventional radiotherapy were compared. Results compared with the control group, the incidence of acute adverse reactions in the IMRT group was lower than that in the control group (P < 0.05), and the incidence of dry mouth, dysphagia, skin reaction and mucosal reaction was lower (P < 0.05), and it was difficult to open the mouth in the late stage injury. There was no significant difference in muscle / soft tissue injury. Conclusion compared with conventional radiotherapy, IMRT can alleviate acute adverse reactions and improve the quality of life of patients.
【学位授予单位】：福建医科大学
【学位级别】：博士
【学位授予年份】：2012
【分类号】：R739.63
本文编号：2255012
[Abstract]:Objective to compare the efficacy and acute and chronic response of intensity modulated radiotherapy and conventional two-dimensional radiotherapy in patients with nasopharyngeal carcinoma. Methods from May 2008 to December 2010, 203 patients with nasopharyngeal carcinoma (NPC) who were treated with conventional radiotherapy and intensity modulated radiotherapy (IMRT) in the Department of radiotherapy, first affiliated Hospital of Fujian Medical University were analyzed systematically. The patients were divided into IMRT group (103 cases) and conventional radiotherapy group (100 cases). The dose of nasopharynx was 660.74 Gy, the enlarged lymph node 64-68 Gy, and the cervical preventive dose 50-52 Gy. Intensity modulated radiotherapy (IMRT) for nasopharyngeal gross neoplasms: GTVnx, neck positive lymph node GTVnd, high risk target volume CTV1 and low risk clinical target volume CTV2:.PTVnx:70.08 1. 81Gy: 67.38 卤2.58Gy PTVl: 61.46 卤2.13Gy PTV2: 54.12 卤2.04Gy, 3133 exposures. The acute adverse reactions such as dry mouth, dysphagia, skin and mucosal reaction in patients with IMRT and conventional radiotherapy were compared. Results compared with the control group, the incidence of acute adverse reactions in the IMRT group was lower than that in the control group (P < 0.05), and the incidence of dry mouth, dysphagia, skin reaction and mucosal reaction was lower (P < 0.05), and it was difficult to open the mouth in the late stage injury. There was no significant difference in muscle / soft tissue injury. Conclusion compared with conventional radiotherapy, IMRT can alleviate acute adverse reactions and improve the quality of life of patients.
【学位授予单位】：福建医科大学
【学位级别】：博士
【学位授予年份】：2012
【分类号】：R739.63
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