声频共振联合全身激素及常规药物治疗突发性聋的随机对照研究

发布时间：2018-10-08 09:27

【摘要】：目的:探讨声频共振联合全身应用激素及常规药物治疗突发性聋(SHL)的近期及远期疗效。方法:将128例SHL患者随机分为对照组(60例)和声频组(68例)。对照组予以全身激素及常规药物治疗;声频组在对照组治疗的基础上,予以声频共振联合外耳道灌注药物(VitB1、VitB12、ATP)治疗。结果:治疗后2周,声频组总有效率为66.18%,对照组为65.00%;治疗后4周,声频组为72.06%,对照组为70.00%;治疗后8周,声频组为73.53%,对照组为68.33%。3个时期2组差异无统计学意义(P0.05)。治疗后4周和8周,声频组平均听阈分别为(43.87±16.73)dB和(40.96±17.11)dB,明显低于对照组(50.89±18.41)dB、(48.93±17.84)dB(P0.05)。治疗中均未出现严重不良事件。结论:应用激素及常规药物治疗可明显降低SHL患者听阈,且安全无明显不良反应,值得临床推广。
[Abstract]:Objective: to investigate the short-and long-term effects of acoustic resonance combined with systemic hormone and routine drugs in the treatment of sudden deafness with (SHL). Methods: 128 patients with SHL were randomly divided into control group (60 cases) and audio group (68 cases). The control group was treated with systemic hormone and routine medicine, and the sound frequency group was treated with acoustic resonance combined with external auditory canal perfusion drug (VitB1,VitB12,ATP) on the basis of the control group. Results: the total effective rate was 66.18 in the audio group and 65.00 in the control group 2 weeks after treatment, 72.06 in the audio group and 70.00in the control group at 4 weeks after treatment, and 73.53 in the audio group and 68.33.3 in the control group at 8 weeks after treatment (P0.05). After 4 weeks and 8 weeks of treatment, the average hearing threshold in the audio group was (43.87 卤16.73) dB and (40.96 卤17.11) dB, respectively, which was significantly lower than that in the control group (50.89 卤18.41) dB, (, 48.93 卤17.84) dB (, P0.05). No serious adverse events occurred in the treatment. Conclusion: hormone and routine drug therapy can significantly reduce the hearing threshold of SHL patients, and the safety has no obvious adverse reactions, so it is worth popularizing in clinic.
【作者单位】：华中科技大学同济医学院附属武汉市中西医结合医院(武汉市第一医院)耳鼻咽喉科;湖北中医药大学临床医学院;
【分类号】：R764.43

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