甲状腺相关眼病眼眶炎症与眼表功能关系探讨
发布时间：2018-10-18 21:07
【摘要】：目的研究甲状腺相关眼病(TAO)患者眼眶炎症水平与眼表功能间相互关系。方法采用横断面病例观察研究。根据改良临床活动性评分将56例TAO患者分为活动期TAO组19例与静止期TAO组37例,并选取无眼表症状正常人20例作为对照组。采用OSDI问卷定量评估眼表症状,测量眼表解剖参数(眼球突出度、睑裂高度、眼睑闭合不全程度)、泪膜破裂时间(TBUT)、角膜荧光素染色(Fl)评分、基础泪液分泌试验(St)。对其中39例TAO患者行结膜印迹细胞学(IC)光镜检查并分级。3组间比较采用单因素方差分析及LSD-t检验,IC检查结果比较采用χ~2检验。结果活动期TAO组与静止期TAO组眼球突出度、睑裂高度、眼睑闭合不全程度比较,差别无统计学意义(P0.05)。活动期TAO组与静止期TAO组TBUT均较对照组缩短(P0.001),Fl评分增高(P0.001),St减少(P0.001)。活动期TAO组较静止期TAO组OSDI评分增高(P0.01),TBUT缩短(P0.001)。IC检查Nelson分级发现,活动期TAO组2~3级比例较静止期TAO组增高(P0.001)。结论TAO患者眼眶炎症可导致泪膜稳定性下降,眼表上皮鳞状化生。
[Abstract]:Objective to study the relationship between orbital inflammation and ocular surface function in patients with thyroid associated ophthalmopathy (TAO). Methods A cross-sectional case study was carried out. According to the modified clinical activity score, 56 patients with TAO were divided into active TAO group (n = 19) and static TAO group (n = 37). OSDI questionnaire was used to quantitatively evaluate ocular surface symptoms, surface anatomical parameters (exophthalmos, height of eyelid fissure, degree of eyelid incompetence), (Fl) score of (TBUT), corneal fluorescein staining for lacrimal film rupture time, and (St). For basic tear secretion test were measured. Among them, 39 cases of TAO were examined by conjunctival blotting cytology (IC) light microscope and graded. The results of three groups were compared by univariate ANOVA and LSD-t test, and the results of IC were compared by 蠂 ~ 2 test. Results there was no significant difference in the degree of exophthalmos, the height of eyelid fissure and the degree of eyelid incompetence between the active TAO group and the rest TAO group (P0.05). TBUT in active TAO group and quiescent TAO group was shorter than that in control group (P0.001), Fl score increased (P0.001), St decreased P0.001). The OSDI score of active TAO group was higher than that of quiescent TAO group (P0. 01), TBUT shortened (P0. 001). IC examination Nelson grade). The ratio of 2 to 3 grade in active TAO group was higher than that in quiescent TAO group (P0. 001). Conclusion Orbital inflammation in TAO patients can lead to the decrease of tear film stability and squamous metaplasia of ocular surface epithelium.
【作者单位】： 福建省立医院眼科;福建医科大学附属协和医院眼科;
【基金】：福建省卫生和计划生育委员会青年科研基金(2015-1-10)
【分类号】：R581;R771.3
本文编号：2280367
[Abstract]:Objective to study the relationship between orbital inflammation and ocular surface function in patients with thyroid associated ophthalmopathy (TAO). Methods A cross-sectional case study was carried out. According to the modified clinical activity score, 56 patients with TAO were divided into active TAO group (n = 19) and static TAO group (n = 37). OSDI questionnaire was used to quantitatively evaluate ocular surface symptoms, surface anatomical parameters (exophthalmos, height of eyelid fissure, degree of eyelid incompetence), (Fl) score of (TBUT), corneal fluorescein staining for lacrimal film rupture time, and (St). For basic tear secretion test were measured. Among them, 39 cases of TAO were examined by conjunctival blotting cytology (IC) light microscope and graded. The results of three groups were compared by univariate ANOVA and LSD-t test, and the results of IC were compared by 蠂 ~ 2 test. Results there was no significant difference in the degree of exophthalmos, the height of eyelid fissure and the degree of eyelid incompetence between the active TAO group and the rest TAO group (P0.05). TBUT in active TAO group and quiescent TAO group was shorter than that in control group (P0.001), Fl score increased (P0.001), St decreased P0.001). The OSDI score of active TAO group was higher than that of quiescent TAO group (P0. 01), TBUT shortened (P0. 001). IC examination Nelson grade). The ratio of 2 to 3 grade in active TAO group was higher than that in quiescent TAO group (P0. 001). Conclusion Orbital inflammation in TAO patients can lead to the decrease of tear film stability and squamous metaplasia of ocular surface epithelium.
【作者单位】： 福建省立医院眼科;福建医科大学附属协和医院眼科;
【基金】：福建省卫生和计划生育委员会青年科研基金(2015-1-10)
【分类号】：R581;R771.3
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