抗过敏治疗对改善儿童慢性鼻-鼻窦炎患者的治疗效果

发布时间：2018-10-24 10:43

【摘要】：目的探讨儿童慢性鼻-鼻窦炎发生的影响因素及观察抗过敏治疗慢性鼻-鼻窦炎儿童的治疗效果。方法选择2013年1月至2015年6月收治的93例慢性鼻-鼻窦炎患者,年龄5~18岁。了解患者家族过敏史、以往过敏史和与过敏反应相关的疾病或症状,所有患者进行身体检查和皮肤过敏性试验。皮试阳性患者接受抗菌药物治疗,抗组胺药物治疗(抗过敏药物),局部糖皮质激素治疗,全身性糖皮质激素治疗及手术治疗后对患者进行随访,评估患者治疗效果。结果患者平均年龄(8.3±6.7)岁,男48例(51.6%),女45例(48.4%)。皮肤过敏性试验结果显示,阳性患者73例(78.5%),其中男38例(52.1%),女35例(47.9%)。阳性患者抗过敏治疗和局部糖皮质激素资料显著改善患者治疗效果,其中抗过敏治疗患者治愈率为97.7%,局部皮质激素治疗和功能性鼻内镜鼻窦术患者治愈率为64.7%和72.3%,抗菌药物治疗不能显著改善患者治疗效果;皮试阳性患者数量与年龄呈负相关。结论慢性鼻-鼻窦炎患者过敏反应或过敏相关症状的发生率较高,过敏反应与慢性鼻-鼻窦炎的发生密切相关;抗过敏治疗和局部糖皮质激素治疗能改善慢性鼻-鼻窦炎患者的临床症状,抗过敏治疗效果优于局部糖皮质激素治疗。
[Abstract]:Objective to investigate the influencing factors of chronic rhinosinusitis in children and to observe the therapeutic effect of anti-allergic therapy on children with chronic rhinosinusitis. Methods 93 patients with chronic rhinosinusitis, aged 5 to 18 years, were selected from January 2013 to June 2015. Understand the patient's family history of allergies, past allergies, and allergy related diseases or symptoms. All patients underwent physical examination and skin allergy tests. Patients with positive skin test received antimicrobial therapy, antihistamine therapy, local glucocorticoid therapy, systemic glucocorticoid therapy and surgical treatment. Results the average age of the patients was (8.3 卤6.7) years, 48 males (51.6%) and 45 females (48.4%). The results of skin anaphylactic test showed that 73 cases (78.5%) were positive, 38 cases (52.1%) were males and 35 cases (47.9%) were females. The antiallergic therapy and local glucocorticoid data in positive patients significantly improved the therapeutic effect. The cure rate of the patients treated with antiallergic therapy was 97.7.The cure rate of local corticosteroid therapy and functional nasal endoscopic sinus surgery was 64.7% and 72.3% respectively. Antimicrobial therapy could not significantly improve the curative effect of the patients, and the number of patients with positive skin test was negatively correlated with age. Conclusion the incidence of allergic reaction or allergy related symptoms in patients with chronic rhinosinusitis is high, and the allergic reaction is closely related to the occurrence of chronic rhinosinusitis. Antiallergic therapy and local glucocorticoid therapy can improve the clinical symptoms of patients with chronic rhinosinusitis and the antiallergic effect is better than that of local glucocorticoid therapy.
【作者单位】：国防科技大学医院五官科;国防科技大学医院保健科;湖南省人民医院耳鼻喉科;
【分类号】：R765.21

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