绝经期女性阻塞性睡眠呼吸暂停综合征的临床特征及影响因素

发布时间：2018-10-29 13:49

【摘要】：目的探讨绝经期女性阻塞性睡眠呼吸暂停综合征(OSAS)的临床特征及其相关风险因素。方法选取绝经期早期OSAS受试者87例、绝经期晚期OSAS受试者86例。测量受试者颈围、腹围;应用Epworth嗜睡量表评价受试者嗜睡程度;多导睡眠监测法检测受试者睡眠呼吸暂停指数(AHI),低通气占AHI的比例,夜间最低血氧饱和度(SpO_2),最长呼吸暂停时间;晨起检测受试者收缩压和舒张压。进一步在两组受试者中进行颈围、腹围以及收缩压,舒张压与AHI的相关分析。结果与绝经期早期组相比,绝经期晚期组表现出嗜睡程度更高以及更高的AHI;低通气所占AHI比例在绝经早期组意义明显高于绝经晚期组(P0.001),夜间最低Sp O2在绝经晚期组较绝经早期组表现为更低(P0.05),最长呼吸暂停时间在两组无统计学差异(P0.05)。腹围和收缩压绝经晚期组高于绝经早期组(P0.05);相关分析结果显示,两组患者腹围与AHI呈正相关(r=0.914,P0.001);AHI与收缩压呈正相关(r=0.822,P0.001)。结论绝经期女性OSAS严重程度随绝经期延长逐渐加重;肥胖是绝经期女性OSAS不可忽视的危险因素,减体重或为预防和治疗绝经期女性OSAS的重要措施;绝经期女性OSAS严重度增高可提高高血压的风险。
[Abstract]:Objective to investigate the clinical features and risk factors of obstructive sleep apnea syndrome (OSAS) in menopausal women. Methods 87 cases of early menopausal OSAS and 86 cases of late menopausal OSAS were selected. The neck circumference and abdominal circumference were measured and the degree of somnolence was evaluated by Epworth somnolence scale. Polysomnography was used to detect the proportion of sleep apnea index (AHI),) hypopnea to AHI, the lowest nocturnal oxygen saturation (SpO_2), the longest apnea time, and the systolic and diastolic blood pressure (DBP). The relationship between neck circumference, abdominal circumference, systolic blood pressure, diastolic blood pressure and AHI was further analyzed in both groups. Results compared with the early menopausal group, the late menopausal group showed higher somnolence and higher AHI;. The percentage of AHI in the early menopausal group was significantly higher than that in the late menopausal group (P0.001), and the lowest Sp O2 at night was lower in the late menopausal group than in the early menopausal group (P0.05). There was no significant difference in the longest apnea time between the two groups (P0.05). The abdominal circumference and systolic blood pressure in late menopausal group were higher than those in early menopausal group (P0.05), and the results of correlation analysis showed that the abdominal circumference was positively correlated with AHI (r = 0.914) P0.001); AHI was positively correlated with systolic blood pressure (r ~ (0.822) P ~ (0.001). Conclusion the severity of OSAS in menopausal women increases gradually with the prolongation of menopausal period, obesity is a risk factor that can not be ignored in menopausal women with OSAS, and weight loss is an important measure to prevent and treat menopausal women with OSAS. A severe increase in OSAS may increase the risk of hypertension in menopausal women.
【作者单位】：吉林大学第一医院呼吸内科;吉林省人民医院神经内科;
【基金】：国家自然科学基金资助项目(81300062) 吉林省卫生厅科技基金资助项目(2013Z007)
【分类号】：R766

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