迎香穴穴位注射联合抗组胺药治疗变应性鼻炎的临床观察

发布时间：2018-11-04 13:26

【摘要】：目的:观察迎香穴穴位注射联合口服抗组胺药治疗变应性鼻炎的临床疗效和安全性。方法:选取我院耳鼻咽喉科门诊收治的变应性鼻炎患者80例(就诊时间为2016年1月至2016年12月期间),随机将80例患者分为观察组和对照组。观察组采用迎香穴穴位注射联合口服抗组胺药的方法,对照组采用口服抗组胺药。穴位注射治疗每周1次,口服抗组胺药物为每日1次,以4周为一个疗程。分别记录患者治疗前、治疗4周后、治疗结束后3个月的临床症状、体征、鼻炎相关生活质量情况,用以评估近、远期临床疗效。采用统计学软件SPSS21.0进行统计学分析,规定当P0.05时,则表示差异有统计学意义性。对两组患者性别、年龄、病程、病情等一般资料进行分析比较,经统计学分析,结果显示差异均无统计学意义,说明组间资料具有可比性。结果:1、临床疗效:(1)治疗4周后,观察组总有效率92.5%,对照组总有效率85%,经检验两组疗效差异有统计学意义(Z=-4.656,P0.001)。(2)治疗结束后3个月,观察组总有效率80%,对照组总有效率55%,经检验两组疗效差异有统计学意义(Z=-4.444,P0.001)。2、症状、体征改善:(1)治疗4周后,组内比较:观察组与对照组对症状、体征的改善在治疗前后均有差异,且差异有统计学意义(观察组:t=16.790,P0.001;对照组:t=16.292,P0.001);组间比较:观察组在改善患者症状上优于对照组,且组间差异有统计学意义(t=-4.51,P0.001)。(2)治疗结束后3个月:组内比较:观察组与对照组对症状、体征的改善在治疗前后均有差异,且差异有统计学意义(t=17.265,P0.001;t=9.531,P0.001);组间比较:观察组在改善患者症状、体征上优于对照组,且组间差异有统计学意义(t=-4.112,P=0.007);3、鼻炎相关生活质量评分改善:(1)治疗4周后,组内比较:观察组与对照组对生活质量评分的改善在治疗前后均有差异,且差异有统计学意义(t=12.549,P0.001;t=-10,P0.001);组间比较:观察组在改善患者鼻炎生活质量分上优于对照组,组间差异有统计学意义(t=4.288,P0.001)。(2)治疗结束后3个月:组内比较:治疗前后观察组和对照组组内鼻炎相关生活质量分改善情况均有统计学差异(t=-5.976,P0.001;t=-3.798,P0.001),组间比较:观察组在改善患者鼻炎生活质量分上优于对照组,组间差异有统计学意义(t=-4.51,P=0.007)。结论:迎香穴穴位注射联合口服抗组胺药和单纯口服抗组胺药治疗变应性鼻炎均可获得一定的近远期临床疗效,穴位注射联合口服抗组胺药的临床疗效优于单纯口服抗组胺药。
[Abstract]:Objective: to observe the clinical efficacy and safety of Yingxiang acupoint injection combined with oral antihistamine in the treatment of allergic rhinitis. Methods: 80 patients with allergic rhinitis (from January 2016 to December 2016) were randomly divided into observation group and control group. The observation group was treated with Yingxiang acupoint injection combined with oral antihistamine, and the control group with oral antihistamine. Acupoint injection was given once a week and oral antihistamine was given once a day for 4 weeks as a course of treatment. The clinical symptoms, signs and quality of life related to rhinitis were recorded before treatment, 4 weeks after treatment and 3 months after treatment. The statistical software SPSS21.0 was used for statistical analysis. When P05 was specified, the difference was statistically significant. The data of sex, age, course of disease and disease were analyzed and compared between the two groups. The results showed that there was no statistical significance between the two groups, which indicated that the data between the two groups were comparable. Results: 1. Clinical efficacy: (1) after 4 weeks of treatment, the total effective rate of the observation group was 92.5 and the total effective rate of the control group was 85. Three months after treatment, the total effective rate of the observation group was 80 and that of the control group was 55. The difference between the two groups was statistically significant (P 0.001). The improvement of physical signs: (1) after 4 weeks of treatment, there were significant differences in the improvement of symptoms and signs between the observation group and the control group after 4 weeks of treatment (observation group: t = 16.790, P 0.001); In the control group: taut 16.292 (P0.001); Comparison between groups: the observation group was superior to the control group in improving the symptoms of the patients, and the difference between the two groups was statistically significant (t _ (-4.51) P _ (0.001). (_ 2) 3 months after the end of the treatment: comparison of the symptoms between the observation group and the control group, there was no significant difference between the observation group and the control group. The improvement of physical signs was different before and after treatment, and the difference was statistically significant (t = 17.265, P 0.001). Comparison between groups: the observation group was superior to the control group in improving the symptoms and signs of the patients, and the difference between the two groups was statistically significant (t = -4.112, P < 0. 007). 3, rhinitis related quality of life score improvement: (1) after 4 weeks of treatment, there were significant differences between the observation group and the control group in the improvement of the quality of life score before and after treatment, and the difference was statistically significant (t = 12.549, P 0.001); T _ (10) (P _ (0.001); Comparison between groups: the quality of life in the observation group was better than that in the control group in improving the quality of life of the patients with rhinitis, and the difference between the two groups was statistically significant (t = 4.288, P < 0.05). P0. 001). (2) 3 months after the end of treatment: intragroup comparison: before and after treatment, the improvement of quality of life related to rhinitis in the observation group and the control group was significantly different (t = 5.976, P 0.001); Comparison between groups: the quality of life in the observation group was better than that in the control group in improving the quality of life of the patients with rhinitis, and the difference between the two groups was statistically significant (t = -4.51, P0. 007). Conclusion: Yingxiang acupoint injection combined with oral antihistamine and oral antihistamine alone can obtain some short-term and long-term clinical efficacy in the treatment of allergic rhinitis. The clinical efficacy of acupoint injection combined with oral antihistamine is better than that of oral antihistamine alone.
【学位授予单位】：西南医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R765.21

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