糖皮质激素联合内镜治疗对鼻息肉患者炎症因子的影响

发布时间：2018-11-04 21:01

【摘要】：目的:探讨糖皮质激素联合内镜治疗对鼻息肉患者血清炎症因子的影响及近期疗效。方法:94例鼻息肉患者,分为观察组(鼻内镜手术联合糖皮质激素治疗,n=45)和对照组(鼻内镜手术治疗,n=49),于手术前和手术后1周时,抽取两组患者清晨静脉血,采用酶联免疫吸附试验法(ELISA)测定血清中白细胞介素2(IL-2)、IL-5及IL-17的水平,比较两组患者术后临床效果及1年复发率。结果:治疗后,观察组患者总有效率91.11%高于对照组;63.27%(χ~2=10.15,P=0.002);治疗前,两组患者血清IL-2、IL-5及IL-17水平比较,差异无统计学意义(P0.05);治疗后,两组患者血清IL-5及IL-17水平低于治疗前(P0.05);治疗后,观察组患者血清IL-5、IL-17水平明显低于对照组(P0.05);观察组患者术后随访1年鼻息肉复发率明显低于对照组(χ~2=4.467,P=0.031)。结论:内镜联合糖皮质激素治疗鼻息肉可以有效减轻患者炎症反应,降低复发率。
[Abstract]:Objective: to investigate the effect of glucocorticoid combined with endoscopic therapy on serum inflammatory factors in nasal polyps. Methods: 94 patients with nasal polyps were divided into two groups: the observation group (nasal endoscopic surgery combined with glucocorticoid therapy, n = 45) and the control group (nasal endoscopic surgery, n = 49). The serum levels of interleukin 2 (IL-2), IL-5 and IL-17 were measured by (ELISA). The clinical effect and recurrence rate of one year were compared between the two groups. Results: after treatment, the total effective rate of patients in the observation group was 91.11% higher than that in the control group, 63.27% (蠂 ~ 2 + 10.15 P < 0.002). Before treatment, there was no significant difference in serum IL-2,IL-5 and IL-17 levels between the two groups (P0.05); after treatment, the levels of serum IL-5 and IL-17 in the two groups were lower than those before treatment (P0.05). After treatment, the serum IL-5,IL-17 level in the observation group was significantly lower than that in the control group (P0.05), and the recurrence rate of nasal polyps in the observation group was significantly lower than that in the control group after 1 year follow-up (蠂 ~ (2) 4.467). Conclusion: endoscopy combined with glucocorticoid can effectively reduce inflammatory reaction and relapse rate of nasal polyps.
【作者单位】：南京中医药大学附属南京市中西医结合医院耳鼻喉科;
【基金】：江苏省中医药科技发展项目(YB2015070)
【分类号】：R765.25

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