离子导入辅助角膜交联治疗青少年圆锥角膜（英文）

发布时间：2018-11-07 19:55

【摘要】：目的:评估离子导入辅助的跨上皮角膜交联治疗青少年圆锥角膜的安全性和有效性。方法:搜集12例(年龄12!18岁,平均15.8±2.08岁)进展期圆锥角膜患者,共15眼,采用0.1%核黄素蒸馏水溶液,离子导入(1 m A电流)辅助跨上皮给药5min,紫外线A(370 nm,3 m W/cm~2)照射30min。记录术前、术后3mo和1a的裸眼视力、最佳矫正视力、K_1、K_2、最大K值、平均K值、角膜散光度数、角膜内皮细胞密度、眼内压、最薄角膜厚度、角膜顶点厚度。角膜参数应用角膜地形图评估,角膜内皮细胞密度应用非接触角膜内皮镜检查。结果:角膜交联1a后,裸眼视力、最佳矫正视力、K_1、K_2、最大K值、平均K值、角膜散光度数、角膜内皮细胞密度和眼内压均无显著变化。最薄角膜厚度从468.08±33.40μm下降到447.46±40.20μm(t=4.379,P=0.001),差异有统计学意义。角膜顶点厚度从476.07±35.96μm下降到454.60±49.32μm(t=4.270,P=0.001),差异有统计学意义。结论:采用0.1%核黄素蒸馏水溶液的离子导入辅助的角膜交联治疗青少年圆锥角膜是安全、有效的,1a内能够阻止病情恶化,但是长期效果有待于进一步观察。
[Abstract]:Objective: to evaluate the safety and efficacy of iontophoresis in the treatment of juvenile keratoconus. Methods: 12 patients (1218 years old, mean 15.8 卤2.08 years) with advanced keratoconus were collected. 15 eyes were treated with 0.1% riboflavin distilled water solution and 1 Ma current for 5 min. Ultraviolet A (370 nm,3 m W/cm~2) was irradiated for 30 min. Preoperative, postoperative 3mo and 1 year uncorrected visual acuity, best corrected visual acuity, K _ (1) K _ (2), maximum K value, mean K value, corneal astigmatism, corneal endothelial cell density, intraocular pressure (IOP), thinnest corneal thickness, corneal vertex thickness were recorded. Corneal parameters were evaluated by corneal topography and corneal endothelial cell density was examined by non-contact keratoendothelium. Results: the naked visual acuity, best corrected visual acuity (BCVA), K _ (1) K _ (2), maximum K value, mean K value, corneal astigmatism, corneal endothelial cell density and intraocular pressure (IOP) had no significant changes after 1 year of corneal crosslinking. The thinnest corneal thickness decreased from 468.08 卤33.40 渭 m to 447.46 卤40.20 渭 m. The corneal vertex thickness decreased from 476.07 卤35.96 渭 m to 454.60 卤49.32 渭 m (t = 4.270). Conclusion: it is safe and effective to treat juvenile keratoconus with 0.1% riboflavin distilled water ion-transfer assisted corneal cross-linking. It can prevent the deterioration of the disease within one year, but the long-term effect needs to be further observed.
【作者单位】：中国人民解放军海军总医院眼科;
【基金】：首都临床特色应用研究与成果推广(北京市科学技术委员会资助:No.Z151100004015217)~~
【分类号】：R772.2

【相似文献】