关于听觉神经编码的分子动力学研究
发布时间：2018-11-21 08:18
【摘要】：耳蜗基底膜振动对声音频率和强度的分辨能力具有重要作用。以往的基底膜振动模型没有考虑外毛细胞主动运动(即电致运动)的不同速度(即延时效应)对基底膜振动的影响,无法全面阐述基底膜振动过程中外毛细胞的主动作用。为此我们介绍了一个新的模型,该模型考虑了外毛细胞电致运动的延时效应。仿真结果显示,新的模型完全符合外毛细胞电致运动的生理特征,从一个新的角度诠释了外毛细胞电致运动对基底膜振动作用的贡献。 膜蛋白Prestin是外毛细胞电致运动的关键元件,对哺乳动物耳蜗放大器和频率选择性至关重要。Prestin作用的发挥受到细胞内氯离子和蛋白质表面电荷的影响,其中氯离子的影响是决定性的。为了研究Prestin转移电荷(即氯离子和蛋白质表面电荷)在受到外加电场作用时对频率和电压的依赖性质,本文介绍一个新的电扩散模型,该模型用Fokker-Plank方程描述Prestin转移电荷的动力学性质。模型分析的结果与实验观察是一致的,有助于对Prestin的结构和功能的进一步分析。
[Abstract]:The vibration of the basal membrane of cochlea plays an important role in the resolution of sound frequency and intensity. Previous models of basement membrane vibration did not take into account the effects of different velocities of outer hair cell active motion (i.e. electroinduced motion) on the vibration of basement membrane, and could not fully explain the active action of outer and outer hair cells in the process of basement membrane vibration. For this reason, we introduce a new model, which takes into account the delay effect of external hair cell electromotion. The simulation results show that the new model fully accords with the physiological characteristics of external hair cell electromotion, and explains the contribution of external hair cell electromotion to the vibration of basement membrane from a new point of view. Membrane protein Prestin is a key element in electroporation of outer hair cells, which plays an important role in mammalian cochlear amplifier and frequency selectivity. The role of Prestin is affected by intracellular chloride ion and surface charge of protein. The influence of chloride ion is decisive. In order to study the dependence of Prestin transfer charge (that is, chloride ion and protein surface charge) on frequency and voltage under the action of external electric field, a new electric diffusion model is introduced in this paper. The Fokker-Plank equation is used to describe the kinetic properties of Prestin transfer charge. The results of the model analysis are consistent with the experimental observation, which is helpful to the further analysis of the structure and function of Prestin.
【学位授予单位】：华东理工大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R764
本文编号：2346421
[Abstract]:The vibration of the basal membrane of cochlea plays an important role in the resolution of sound frequency and intensity. Previous models of basement membrane vibration did not take into account the effects of different velocities of outer hair cell active motion (i.e. electroinduced motion) on the vibration of basement membrane, and could not fully explain the active action of outer and outer hair cells in the process of basement membrane vibration. For this reason, we introduce a new model, which takes into account the delay effect of external hair cell electromotion. The simulation results show that the new model fully accords with the physiological characteristics of external hair cell electromotion, and explains the contribution of external hair cell electromotion to the vibration of basement membrane from a new point of view. Membrane protein Prestin is a key element in electroporation of outer hair cells, which plays an important role in mammalian cochlear amplifier and frequency selectivity. The role of Prestin is affected by intracellular chloride ion and surface charge of protein. The influence of chloride ion is decisive. In order to study the dependence of Prestin transfer charge (that is, chloride ion and protein surface charge) on frequency and voltage under the action of external electric field, a new electric diffusion model is introduced in this paper. The Fokker-Plank equation is used to describe the kinetic properties of Prestin transfer charge. The results of the model analysis are consistent with the experimental observation, which is helpful to the further analysis of the structure and function of Prestin.
【学位授予单位】：华东理工大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R764
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