鼻咽癌调强放疗期间的急性放射性反应与体重下降的相关性

发布时间：2018-11-21 17:25

【摘要】：目的:分析鼻咽癌患者放疗期间的体重下降和急性放射性反应这两大影响患者生存质量因素之间的关系,为临床上提高患者生存质量提供依据。方法:分别用二变量相关分析和线性回归分析两种统计学方法分析2002年6月至2006年8月间在中山大学附属肿瘤医院接受了根治性调强放射治疗的322例初治鼻咽癌患者放疗期间的体重下降和急性放射性反应的关系。结果:在全部的322例患者中,93.5%的患者出现体重下降,体重下降平均值为6.85%的放疗前体重。最常见的急性反应分别出现在皮肤、黏膜和唾液腺。用二变量相关分析发现,皮肤(P=0.002)、黏膜(P0.001)、咽和食管(P0.001)以及上消化道(P=0.003)等急性放射性反应因素与体重下降呈正相关;用多重线性回归分析发现,AJCC N分期(P=0.008)、是否化疗(P=0.018)和黏膜(P=0.005)、咽和食管(P0.001)以及上消化道(P=0.047)的急性放射性反应是独立影响调强放疗期间体重下降的因素。结论:调强放疗引起的急性放射性反应可直接影响鼻咽癌患者放疗期间的体重下降。
[Abstract]:Objective: to analyze the relationship between weight loss and acute radiation response in patients with nasopharyngeal carcinoma (NPC) during radiotherapy. Methods: from June 2002 to August 2006, 322 cases of nasopharyngeal carcinoma treated with radical intensity modulated radiotherapy (IMRT) from June 2002 to August 2006 were analyzed with two variables correlation analysis and linear regression analysis. Relationship between weight loss and acute radiation response during radiotherapy. Results: of 322 patients, 93.5% had weight loss and the average weight loss was 6.85% before radiotherapy. The most common acute reactions occur in the skin, mucosa, and salivary glands, respectively. The acute radioactivity factors such as skin (P0. 002), mucous membrane (P0. 001), pharynx and esophagus (P0. 001) and upper digestive tract (P0. 003) were positively correlated with weight loss. Multiple linear regression analysis showed that, AJCC N stage (P0. 008), chemotherapy (P0. 018) and mucous membrane (P0. 005), Acute radioactivity in pharynx and esophagus (P0.001) and upper digestive tract (P0. 047) were independent factors affecting weight loss during IMRT. Conclusion: the acute radiation response induced by IMRT can directly affect the weight loss in patients with nasopharyngeal carcinoma during radiotherapy.
【作者单位】：广州医科大学附属肿瘤医院放疗科;中山大学附属肿瘤医院放疗科;
【基金】：广州市科技局项目(编号:2009Z1-E281)
【分类号】：R739.63

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