丝裂霉素不同给药剂量治疗复发性翼状胬肉疗效对比

发布时间：2018-12-11 01:00

【摘要】：目的:分析丝裂霉素不同给药剂量治疗复发性翼状胬肉疗效。方法:选取接受复发性翼状胬肉治疗的患者240例,均给予单纯的翼状胬肉切除手术治疗,随机分为三组,低剂量组患者80例,给予0.15 g/L丝裂霉素结膜下注射治疗;中剂量组80例,给予常规剂量0.25 g/L丝裂霉素结膜下注射;高剂量组患者80例,给予0.40 g/L丝裂霉素结膜下注射,对比三组患者的治疗效果。结果:高剂量组患者的治疗效果与中剂量组、低剂量组患者的临床治疗总有效率比较差异无统计学意义(P0.05)。三组患者的不良反应发生率比较差异具有统计学意义(P0.05)。结论:对于复发性翼状胬肉给予0.15 g/L、0.25 g/L、0.40 g/L剂量的丝裂霉素结膜下注射,能够获得较好的临床治疗效果,临床治疗效果相似,但合并症发生比较存在差异,0.15 g/L结膜下注射丝裂霉素治疗效果最佳,不良反应最低,适宜临床治疗应用。
[Abstract]:Objective: to analyze the curative effect of different dosage of mitomycin on recurrent pterygium. Methods: 240 patients with recurrent pterygium were treated with simple pterygium excision and were randomly divided into three groups. 80 patients in the low dose group were treated with 0.15 g / L subconjunctival injection of mitomycin. 80 patients in the middle dose group were given subconjunctival injection of 0.25 g / L mitomycin and 80 patients in the high dose group were given 0.40 g / L mitomycin subconjunctival injection. Results: there was no significant difference in the total effective rate between the high dose group and the middle dose group and the low dose group (P0.05). The incidence of adverse reactions in the three groups was significantly different (P0.05). Conclusion: subconjunctival injection of 0.15 g / L 0.25 g / L 0.40 g / L mitomycin for recurrent pterygium can obtain better clinical therapeutic effect, and the clinical treatment effect is similar. However, the incidence of complications is different, 0.15 g / L subconjunctival injection of mitomycin is the best treatment, the lowest adverse reaction, suitable for clinical use.
【作者单位】：越秀区华乐街社区卫生服务中心;河源东江眼病防治所;
【分类号】：R777.33

【相似文献】