前房注射头孢呋辛预防白内障术后眼内炎的临床效果

发布时间：2018-12-12 14:38

【摘要】：目的探讨白内障术末前房注射头孢呋辛对眼内炎发生率的影响,评价该预防措施的临床效果。方法回顾性研究2009-2015年在我科接受白内障手术的10 515眼患者资料,统计各年份白内障患者中接受前房注射头孢呋辛的比例、眼内炎的发生率及逐年累积发生率。对术后眼内炎患者的年龄、性别、视力、病原菌及接受注射的情况进行分析。结果过去7 a接受白内障手术者5995例(10 515眼),其中9382眼(89.2%)接受了前房注射头孢呋辛1 mg/0.1 m L。随着头孢呋辛前房注射比例的增加,感染性眼内炎发生率由0.182%(2009年)降至0.072%(2011年),7 a总体累积发生率为0.038%(95%CI,0.001-0.075)。2009-2011年白内障术后发生眼内炎4例,平均潜伏期3.75 d。2012-2015年无眼内炎病例发生。所有接受注射的患者未发生药物毒性及过敏反应。结论白内障术末前房注射1 mg/0.1 m L头孢呋辛安全有效,术后眼内炎的发生率明显降低,有望作为白内障围手术期预防感染的常规措施。
[Abstract]:Objective to investigate the effect of cefuroxime injection on the incidence of endophthalmitis at the end of cataract surgery. Methods the data of 10 515 eyes who underwent cataract surgery in our department from 2009 to 2015 were retrospectively studied. The rate of anterior chamber injection of cefuroxime, the incidence of endophthalmitis and the cumulative incidence of endophthalmitis were analyzed. Age, sex, visual acuity, pathogenic bacteria and injection were analyzed in patients with endophthalmitis after operation. Results 5995 cases (10 515 eyes) underwent cataract surgery in the past 7 years, of which 9382 eyes (89.2%) received anterior chamber injection of cefuroxime 1 mg/0.1 mL. With the increase of cefuroxime injection in anterior chamber, the incidence of infective endophthalmitis decreased from 0.182% (2009) to 0.072% (2011), and the overall cumulative incidence in 7 years was 0.038% (95% CI). There were 4 cases of endophthalmitis after cataract operation from 2009 to 2011, with an average latency of 3.75 d.2012-2015. There were no cases of endophthalmitis. No drug toxicity or allergic reaction occurred in all patients receiving the injection. Conclusion 1 mg/0.1 L cefuroxime injection at the end of cataract surgery is safe and effective, and the incidence of postoperative endophthalmitis is obviously reduced.
【作者单位】：上海交通大学医学院附属第九人民医院眼科;
【基金】：国家自然科学基金资助(编号:81300773)~~
【分类号】：R779.66

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