雷珠单抗联合小梁切除术及全视网膜光凝治疗新生血管性青光眼的临床观察

发布时间：2019-01-05 19:48

【摘要】：目的观察玻璃体内注射雷珠单抗联合小梁切除术及全视网膜光凝(panretinal photocoagulation,PRP)治疗新生血管性青光眼(neovascular glaucoma,NVG)的临床疗效。方法选取2013年1月至2014年12月我院收治的NVG患者60例(80眼),均采用玻璃体内注射雷珠单抗联合小梁切除术及PRP治疗,术后随访1~6个月,观察患者术后一般疗效、视力、眼压及并发症等情况。结果 80眼中手术完全成功70眼,条件成功6眼,失败4眼,手术成功率为95.0%。与术前比较,术后1周、1个月、6个月视力均有不同程度提高(P0.05)。术前、术后1周、1个月、6个月眼压分别为(35.2±2.8)mm Hg(1 k Pa=7.5 mmHg)、(17.4±1.3)mm Hg、(18.2±1.6)mm Hg、(18.4±1.5)mm Hg,与术前比较,术后1周、1个月、6个月眼压均下降,差异均有显著统计学意义(均为P0.01)。术后1周形成功能性滤过泡58眼(82.9%),非功能性滤过泡12眼(17.1%);术后6个月形成功能性滤过泡62眼(77.5%),非功能性滤过泡18眼(22.5%)。术后并发症主要包括前房积血、浅前房、前部葡萄膜炎、玻璃体积血等。结论玻璃体内注射雷珠单抗联合小梁切除术及PRP治疗NVG能显著控制眼压,并发症较少。
[Abstract]:Objective to observe the clinical effect of intravitreal injection of Lei Zhu McAb combined with trabeculectomy and total retinal photocoagulation (panretinal photocoagulation,PRP) in the treatment of neovascular glaucoma (neovascular glaucoma,NVG). Methods from January 2013 to December 2014, 60 patients (80 eyes) with NVG were treated with intravitreous injection of Lei Zhu McAb combined with trabeculectomy and PRP. The patients were followed up for 1 to 6 months. The general curative effect and visual acuity of the patients were observed. Intraocular pressure and complications. Results in 80 eyes, the operation was completely successful in 70 eyes, conditional success in 6 eyes, failure in 4 eyes, and the successful rate of operation was 95.0. Compared with preoperative, visual acuity was improved 1 week, 1 month and 6 months postoperatively (P0.05). Intraocular pressure (IOP) was (35.2 卤2.8) mm Hg () 1 k Pa=7.5 mmHg), (17.4 卤1.3) mm Hg, (18.2 卤1.6) mm Hg, (18.4 卤1.5) mm Hg, before operation, 1 week, 1 month and 6 months after operation, respectively. IOP decreased 1 week, 1 month and 6 months postoperatively (all P 0.01). Functional blebs were found in 58 eyes (82.9%) and non-functional blebs in 12 eyes (17.1%) at 1 week, and functional blebs in 62 eyes (77.5%) and non-functional blebs in 18 eyes (22.5%) 6 months after operation. Postoperative complications include hyphema, superficial anterior chamber, anterior uveitis and vitreous hemorrhage. Conclusion intravitreous injection of Lei Zhu McAb combined with trabeculectomy and PRP can significantly control intraocular pressure (IOP) with less complications.
【作者单位】：南阳市第二人民医院眼科;
【分类号】：R779.6

【相似文献】