i-MP对产生2型CNV的AMD患者最佳矫正视力及黄斑厚度的影响

发布时间：2019-01-08 09:38

【摘要】：目的研究吲哚青绿介导的光栓疗法对年龄相关性黄斑变性所致的经典型脉络膜新生血管患者的最佳矫正视力及黄斑厚度的影响。方法 11例(12眼)经视网膜、脉络膜血管造影确诊为经典型脉络膜新生血管的AMD患者,静脉注射吲哚青绿溶液后,进行低强度、大光斑、持续的激光照射。每次治疗后3个月,根据吲哚青绿血管造影及视网膜荧光血管造影,决定是否进行再次治疗(不超过3次)。结果经过12个月的随访,最佳矫正视力不变(提高或下降少于2行)5只眼(41.7%),提高超过2行5只眼(41.7%),下降超过2行2只眼。治疗前黄斑中心厚度为(391±69.89)u m,12周、48周后分别为(337±56.23)u m、(332±62.07)u m,前后的差异有统计学意义(P0.05)。光学相干断层扫描证实83.3%的患者黄斑中心凹厚度有所下降且黄斑形态改善。复查视网膜荧光血管造影、吲哚青绿血管造影显示：荧光渗漏在经典脉络膜新生血管组织中消失7只眼,明显减轻3只眼,加重或者无明显好转2只眼。治疗中无明显的并发症发生。结论吲哚青绿介导的光栓疗法是一种对年龄相关性黄斑变性的黄斑下脉络膜新生血管行之有效的治疗方法。
[Abstract]:Objective to study the effects of indocyanine green mediated photoembolization on the best corrected visual acuity and macular thickness in patients with classic choroidal neovascularization due to age-related macular degeneration. Methods 11 cases (12 eyes) of AMD with classic choroidal neovascularization diagnosed by retinal and choroidal angiography were treated with low intensity, large light spot and continuous laser irradiation after intravenous injection of indocyanine green solution. After 3 months of treatment, indocyanine green angiography and retinal fluorescein angiography were used to determine whether to retreat (no more than 3 times). Results after 12 months follow-up, the best corrected visual acuity (BCVA) remained unchanged (improved or decreased less than 2 rows) in 5 eyes (41.7%), improved more than 2 rows in 5 eyes (41.7%), decreased more than 2 rows in 2 eyes. The mean central macular thickness was (391 卤69.89) u / min before treatment and (337 卤56.23) u m, (/ 332 卤62.07) u m,) after 48 weeks respectively (P0.05). Optical coherence tomography (OCT) showed that macular fovea thickness decreased and macular morphology improved in 83.3% of the patients. In retina fluorescein angiography, indocyanine green angiography showed that fluorescence leakage disappeared in 7 eyes in classical choroidal neovascularization, significantly reduced in 3 eyes, aggravated or did not improve in 2 eyes. No obvious complications occurred in the treatment. Conclusion Indocyanine green mediated photoembolization is an effective treatment for submacular choroidal neovascularization in age-related macular degeneration.
【学位授予单位】：郑州大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R774.5

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