良性阵发性位置性眩晕患者存在血清25-羟维生素D水平下降
发布时间：2019-01-14 17:03
【摘要】：目的初步探讨血清25-羟维生素D[25(OH)D]在良性阵发性位置性眩晕(BPPV)发生、复发中的作用。方法纳入2013年1月至2014年12月在上海交通大学医学院附属第九人民医院神经内科诊治的部分BPPV患者,根据1年随访结果,分为BPPV未复发组(n=207)及复发组(n=42),并将同期收治的其他眩晕病患者作为对照(n=43),比较3组患者血清25(OH)D水平的差异,并分析影响所有受试者血清25(OH)D水平的独立相关因素。结果与眩晕对照组相比,BPPV未复发组、复发组血清25(OH)D水平均下降(P均0.01),而复发组与未复发组血清25(OH)D水平差异无统计学意义。BPPV复发组女性比例较其余两组略增高,但差异无统计学意义(P=0.073)。所有入组患者中女性血清25(OH)D水平低于男性[(18.7±7.5)ng/mL vs(21.7±8.3)ng/mL,P=0.002]。多因素逐层线性回归分析显示女性(β=-2.6,P=0.005)、BPPV(β=-5.5,P0.001)是患者血清25(OH)D水平的独立影响因素。结论人血清25(OH)D水平存在性别差异,BPPV患者25(OH)D水平下降。
[Abstract]:Objective to investigate the role of serum 25 hydroxyvitamin D [25 (OH) D] in the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV). Methods from January 2013 to December 2014, some BPPV patients treated in the Department of Neurology, Ninth people's Hospital, School of Medicine, Shanghai Jiaotong University, were included. According to the results of 1-year follow-up, the patients were divided into two groups: no recurrent BPPV group (nx207) and relapsed group (NX42). Other vertigo patients treated in the same period were used as control group (nnf43) to compare the difference of serum 25 (OH) D level among the three groups, and to analyze the independent factors affecting the serum 25 (OH) D level of all the subjects. Results compared with the vertigo control group, the serum 25 (OH) D level in the BPPV group and the relapsing group decreased significantly (P 0.01). However, there was no significant difference in serum 25 (OH) D level between relapsed group and non-recurrent group. The proportion of female in recurrent BPPV group was slightly higher than that in the other two groups, but the difference was not statistically significant (P0. 073). The serum 25 (OH) D level in women was lower than that in males [(18.7 卤7.5) ng/mL vs (21.7 卤8.3) ng/mL,P=0.002]. Multivariate linear regression analysis showed that women (尾 = -2.6), BPPV (尾 = -5.5), BPPV (P 0.001) were independent factors of serum 25 (OH) D level. Conclusion there is a gender difference in serum 25 (OH) D level, and 25 (OH) D level in BPPV patients is decreased.
【作者单位】： 上海交通大学医学院附属第九人民医院神经内科;
【基金】：上海交通大学医学院(理学)基金(14XJ10063)~~
【分类号】：R764
本文编号：2408906
[Abstract]:Objective to investigate the role of serum 25 hydroxyvitamin D [25 (OH) D] in the occurrence and recurrence of benign paroxysmal positional vertigo (BPPV). Methods from January 2013 to December 2014, some BPPV patients treated in the Department of Neurology, Ninth people's Hospital, School of Medicine, Shanghai Jiaotong University, were included. According to the results of 1-year follow-up, the patients were divided into two groups: no recurrent BPPV group (nx207) and relapsed group (NX42). Other vertigo patients treated in the same period were used as control group (nnf43) to compare the difference of serum 25 (OH) D level among the three groups, and to analyze the independent factors affecting the serum 25 (OH) D level of all the subjects. Results compared with the vertigo control group, the serum 25 (OH) D level in the BPPV group and the relapsing group decreased significantly (P 0.01). However, there was no significant difference in serum 25 (OH) D level between relapsed group and non-recurrent group. The proportion of female in recurrent BPPV group was slightly higher than that in the other two groups, but the difference was not statistically significant (P0. 073). The serum 25 (OH) D level in women was lower than that in males [(18.7 卤7.5) ng/mL vs (21.7 卤8.3) ng/mL,P=0.002]. Multivariate linear regression analysis showed that women (尾 = -2.6), BPPV (尾 = -5.5), BPPV (P 0.001) were independent factors of serum 25 (OH) D level. Conclusion there is a gender difference in serum 25 (OH) D level, and 25 (OH) D level in BPPV patients is decreased.
【作者单位】： 上海交通大学医学院附属第九人民医院神经内科;
【基金】：上海交通大学医学院(理学)基金(14XJ10063)~~
【分类号】：R764
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，本文编号：2408906
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