鼻声反射对特异性变应原皮下免疫治疗儿童变应性鼻炎的疗效评估

发布时间：2019-01-24 17:17

【摘要】：目的探讨鼻声反射测量评估特异性变应原皮下免疫治疗变应性鼻炎的疗效。方法对接受阿罗格(螨变应原注射液)皮下注射脱敏治疗的65例变应性鼻炎患儿进行研究,其中男40例,女25例;年龄5~13岁,平均年龄(7.1±2.2)岁。所有患儿均对屋尘螨和粉尘螨过敏,完成1年的特异性皮下免疫治疗。治疗前和治疗后1年分别进行症状评分和鼻声反射测量,分析治疗前后鼻腔容积(NV)及鼻腔最小横截面积(MCA)的变化,评估特异性变应原皮下免疫治疗的疗效。结果 65例变应性鼻炎患儿特异性变应原皮下免疫治疗1年后症状评分明显改善,治疗1年后鼻腔容积及鼻腔最小横截面积与治疗前相比显著增加。结论鼻声反射测量是客观反映鼻腔通气状况的指标。鼻声反射测定值与患者主观感受具有高度一致性,对鼻腔通气功能的临床评估有应用价值。特异性变应原皮下免疫治疗变应性鼻炎疗效确切,用鼻声反射测量来评估是客观准确的。
[Abstract]:Objective to evaluate the efficacy of specific allergen subcutaneous immunotherapy for allergic rhinitis. Methods Sixty-five children with allergic rhinitis received subcutaneous desensitization of arogee injection were studied, including 40 males and 25 females, with a mean age of (7.1 卤2.2) years (mean age of (7.1 卤2.2) years). All the children were allergic to house dust mites and completed 1 year specific subcutaneous immunotherapy. Symptom score and nasal acoustic reflex were measured before and one year after treatment. The changes of nasal volume (NV) and minimum cross sectional area of nasal cavity (MCA) were analyzed before and after treatment to evaluate the efficacy of specific allergen subcutaneous immunotherapy. Results the symptom scores of 65 children with allergic rhinitis were significantly improved after 1 year of specific allergen subcutaneous immunotherapy. The volume of nasal cavity and the minimum cross sectional area of nasal cavity were significantly increased after one year of treatment. Conclusion the measurement of nasal acoustic reflex is an objective index of nasal ventilation. The measurement of nasal acoustic reflex is highly consistent with the subjective feeling of the patients. It is valuable for the clinical evaluation of nasal ventilation function. Specific allergen subcutaneous immunotherapy is effective in the treatment of allergic rhinitis.
【作者单位】：广州市妇女儿童医疗中心耳鼻咽喉科;
【基金】：广州市医药卫生项目(20151A010042)
【分类号】：R765.21

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