鼻咽拭子EB病毒DNA检测在鼻咽癌诊断中的价值
发布时间：2019-01-27 16:54
【摘要】：目的探讨EB病毒(EBV)-DNA检测方法及其在鼻咽癌(NPC)早期诊断中的价值。方法应用聚合酶链反应(PCR)荧光定量检测185例疑诊NPC患者鼻咽拭子及外周血EBV-DNA,并进行比较分析。185例疑诊NPC患者最终病理确诊为NPC 141例(NPC组),其余44例为非NPC组。结果 2组患者鼻咽拭子EB病毒DNA检测的阳性率均较外周血检测的阳性率高,差异有统计学意义;鼻咽拭子EBV-DNA检测在2组间差异有统计学意义(P0.05);外周血EBV-DNA检测在2组间差异无统计学意义(P0.05)。结论鼻咽拭子EBV-DNA检测较外周血更为敏感,有助于NPC的早期诊断。
[Abstract]:Objective to investigate the detection method of EB virus (EBV)-DNA and its value in the early diagnosis of nasopharyngeal carcinoma (NPC) (NPC). Methods Polymerase chain reaction (PCR) fluorescence quantitative detection of nasopharyngeal swabs and peripheral blood EBV-DNA, in 185 patients with suspected NPC was performed. The final pathological diagnosis of 185 patients with suspected NPC was NPC (NPC group), while the remaining 44 cases were non-NPC group. Results the positive rate of nasopharyngeal swab EB virus DNA in both groups was higher than that in peripheral blood, and the difference was statistically significant (P0.05). There was no significant difference between the two groups in the detection of peripheral blood EBV-DNA (P0.05). Conclusion the detection of nasopharyngeal swab EBV-DNA is more sensitive than that of peripheral blood, which is helpful for the early diagnosis of NPC.
【作者单位】： 云南省红河哈尼族彝族自治州第三人民医院肿瘤分子与细胞生物学实验中心;重庆市人民医院(三院院区)耳鼻咽喉头颈外科;
【分类号】：R739.63
，
本文编号：2416484
[Abstract]:Objective to investigate the detection method of EB virus (EBV)-DNA and its value in the early diagnosis of nasopharyngeal carcinoma (NPC) (NPC). Methods Polymerase chain reaction (PCR) fluorescence quantitative detection of nasopharyngeal swabs and peripheral blood EBV-DNA, in 185 patients with suspected NPC was performed. The final pathological diagnosis of 185 patients with suspected NPC was NPC (NPC group), while the remaining 44 cases were non-NPC group. Results the positive rate of nasopharyngeal swab EB virus DNA in both groups was higher than that in peripheral blood, and the difference was statistically significant (P0.05). There was no significant difference between the two groups in the detection of peripheral blood EBV-DNA (P0.05). Conclusion the detection of nasopharyngeal swab EBV-DNA is more sensitive than that of peripheral blood, which is helpful for the early diagnosis of NPC.
【作者单位】： 云南省红河哈尼族彝族自治州第三人民医院肿瘤分子与细胞生物学实验中心;重庆市人民医院(三院院区)耳鼻咽喉头颈外科;
【分类号】：R739.63
，
本文编号：2416484
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