治疗前PLR和NLR对鼻咽癌患者预后的影响

发布时间：2019-03-20 18:52

【摘要】：目的探讨鼻咽癌患者治疗前外周血中血小板与淋巴细胞比(platelet-lymphocyte ratio,PLR)、中性粒细胞与淋巴细胞比(neutrophil-lymphocyte ratio,NLR)与总生存期(overall survival,OS)、无进展生存期(progression-free survival,PFS)的相关性。方法回顾性分析西安交通大学第一附属医院和陕西省人民医院2009年1月至2013年9月期间初治的91例鼻咽癌患者临床资料,根据ROC曲线选取PLR和NLR的截断值,将患者根据截断值分组,采用Kaplan-Meier法和Log rank检验比较不同组患者的总生存率和无进展生存率,应用Cox比例风险模型进行单因素和多因素分析。结果当PLR=143.3、NLR=2.6时,对患者的预后预测价值最高。Cox多因素分析发现PLR≥143.3(RR=2.491,95%CI=1.139~5.451,P=0.022)、NLR≥2.6(RR=2.186,95%CI=1.021~4.682,P=0.044)时,患者的OS较短,而PLR≥143.3(RR=2.461,95%CI=1.242~4.874,P=0.01)时,患者的PFS较差。结论治疗前PLR和NLR可能是影响鼻咽癌患者预后的独立危险因素。
[Abstract]:Objective to investigate the platelet to lymphocyte ratio (platelet-lymphocyte ratio,PLR), neutrophil to lymphocyte ratio (neutrophil-lymphocyte ratio,NLR), total survival time (overall survival,OS) and progression-free survival time (progression-free survival,) in peripheral blood of patients with nasopharyngeal carcinoma (NPC) before treatment. PFS). Methods the clinical data of 91 patients with nasopharyngeal carcinoma in the first affiliated Hospital of Xi'an Jiaotong University and people's Hospital of Shaanxi Province from January 2009 to September 2013 were retrospectively analyzed. According to the ROC curve, the cut-off values of PLR and NLR were selected. The patients were divided into two groups according to the cut-off value. Kaplan- Meier method and Log rank test were used to compare the overall survival rate and the progression-free survival rate in different groups. The Cox proportional hazard model was used for univariate and multivariate analysis. Results when PLR=143.3,NLR=2.6 was used, the prognostic value was the highest. Cox multivariate analysis showed that PLR 鈮，

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