视网膜静脉阻塞黄斑水肿的多焦视网膜电图与光学相干断层扫描分析

发布时间：2019-04-08 14:51

【摘要】：目的探讨视网膜静脉阻塞(retinal vein occlusion,RVO)继发黄斑水肿(macula edema,ME)患者多焦视网膜电图(multifocal electroretinogram,mf-ERG)和光学相干断层扫描(optical coherence tomography,OCT)的特征。方法对38例(38眼)确诊为RVO继发ME患者进行mf-ERG及OCT检查,选取同期门诊中正常人23例(23眼)作为正常对照组。OCT用于测量直径1.0 mm黄斑中心圆形区的黄斑视网膜厚度(macular retinal thickness,)CMT,mf-ERG评价黄斑部视网膜功能,并分析环1~环5中P1波振幅密度及P1、N1波潜伏期变化。结果与正常对照组比较,BRVO组:P1波振幅密度在环2(35.95±17.04)nV·deg-2,环3(24.72±8.32)nV·deg-2,环4(19.28±6.38)nV·deg-2,环5(13.49±6.16)nV·deg-2显著下降(均为P0.05);P1波潜伏期在环2(35.74±3.72)ms有明显延迟(P0.05);N1波潜伏期在环2(18.43±4.63)ms、环3(18.67±2.86)ms有明显延迟(均为P0.05)。与正常对照组比较,CRVO组:P1波振幅密度在环1(81.58±43.15)nV·deg-2、环2(33.71±9.81)nV·deg-2、环3(22.15±9.75)nV·deg-2、环4(16.65±6.38)nV·deg-2、环5(14.18±4.59)nV·deg-2显著下降(均为P0.05);P1波潜伏期在环2(37.56±5.55)ms、环3(37.31±5.22)ms、环4(35.71±5.63)ms、环5(37.30±5.37)ms有明显延迟(均为P0.05);N1波潜伏期在环1(21.82±5.76)ms、环2(19.18±4.82)ms、环3(19.31±4.25)ms、环4(19.05±4.55)ms、环5(19.43±4.12)ms有明显延迟(均为P0.05)。CRVO组CMT与mf-ERG环1中P1振幅密度呈负相关(r=-0.576,P0.05)。结论 OCT与mfERG相结合能更好地反映RVO继发ME患者的黄斑部视网膜形态与功能变化。
[Abstract]:Objective to investigate the characteristics of multifocal electroretinogram (multifocal electroretinogram,mf-ERG) and optical coherence tomography (optical coherence tomography,OCT) in patients with macular edema (macula edema,ME) secondary to retinal vein occlusion (retinal vein occlusion,RVO). Methods mf-ERG and OCT were performed in 38 patients (38 eyes) with RVO secondary ME. 23 normal subjects (23 eyes) were selected as the control group. Oct was used to measure the thickness of macular retina in the central round area of 1.0 mm macular area. (macular retinal thickness,) CMT,mf-ERG was used to evaluate the macular retinal function. The amplitude density of P1 wave and the latencies of P1 and N1 in rings 1 ~ 5 were analyzed. Results in BRVO group, the amplitude densities of P1 wave were (35.95 卤17.04) nV 路deg-2, (24.72 卤8.32) nV 路deg-2, (19.28 卤6.38) nV 路deg-2 in loop 2, (24.72 卤8.32) nV 路deg-2 and (19.28 卤6.38) nV 路deg-2, respectively. Ring 5 (13.49 卤6.16) nV 路deg-2 decreased significantly (P 0.05); The latency of P1 wave was significantly delayed in ring 2 (35.74 卤3.72) ms (P0.05), and that of N1 wave in ring 2 (18.43 卤4.63) ms, ring 3 (18.67 卤2.86) ms was significantly delayed (P0.05). In CRVO group, the amplitude density of P1 wave was (81.58 卤43.15) nV 路deg-2 in ring 1, (33.71 卤9.81) nV 路deg-2 in ring 2, and (22.15 卤9.75) nV 路deg-2 in loop 3. Ring 4 (16.65 卤6.38) nV 路deg-2, ring 5 (14.18 卤4.59) nV 路deg-2 decreased significantly (P 0.05); The latency of P1 wave was significantly delayed in ring 2 (37.56 卤5.55) ms, ring 3 (37.31 卤5.22) ms, ring 4 (35.71 卤5.63) ms, ring 5 (37.30 卤5.37) ms (P 0.05). The latencies of N1 wave in ring 1 (21.82 卤5.76) ms, ring 2 (19.18 卤4.82) ms, ring 3 (19.31 卤4.25) ms, ring 4 (19.05 卤4.55) ms, There was a significant delay in ring 5 (19.43 卤4.12) ms (P 0.05). There was a negative correlation between CMT in). CRVO group and P1 amplitude density in mf-ERG loop 1 (r = 0.576, P0.05). Conclusion the combination of OCT and mfERG can better reflect the morphological and functional changes of macular retina in patients with ME secondary to RVO.
【作者单位】：西安市第四医院眼科;
【基金】：陕西省科技厅社会发展科技攻关项目(编号:2015SF232;2015SF085;2015SF106) 西安市科技局社会发展引导计划-医学研究项目[编号:SF1513(3)]~~
【分类号】：R774.1

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